Regulation of GPCR-mediated smooth muscle contraction: Implications for asthma and pulmonary hypertension

D. B. Wright, S. Tripathi, A. Sikarwar, K. T. Santosh, J. Perez-Zoghbi, O. O. Ojo, N. Irechukwu, J. P. T. Ward, D. Schaafsma*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    33 Citations (Scopus)

    Abstract

    Contractile G-protein-coupled receptors (GPCRs) have emerged as key regulators of smooth muscle contraction, both under healthy and diseased conditions. This brief review will discuss some key topics and novel insights regarding GPCR-mediated airway and vascular smooth muscle contraction as discussed at the 7th International Young Investigators' Symposium on Smooth Muscle (2011, Winnipeg, Manitoba, Canada) and will in particular focus on processes driving Ca2+-mobilization and -sensitization. (C) 2012 Elsevier Ltd. All rights reserved.

    Original languageEnglish
    Pages (from-to)121-131
    Number of pages11
    JournalPULMONARY PHARMACOLOGY AND THERAPEUTICS
    Volume26
    Issue number1
    DOIs
    Publication statusPublished - Feb 2013

    Keywords

    • Calcium
    • Ca2+-mobilization
    • Ca2+-sensitization
    • CPI-17
    • Palmitoylation
    • ROCK
    • PROTEIN-KINASE-C
    • MYOSIN LIGHT-CHAIN
    • BETA-GAMMA-SUBUNITS
    • AIRWAY HYPERRESPONSIVE RATS
    • ENDOTHELIN-INDUCED CONTRACTION
    • OPERATED CALCIUM-CHANNEL
    • NITRIC-OXIDE SYNTHASE
    • TRIMERIC G-PROTEINS
    • CA2+ SENSITIZATION
    • RHO-KINASE

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