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Regulation of RNA Polymerase II Transcription Initiation and Elongation by Transcription Factor TFII-I

Research output: Contribution to journalReview articlepeer-review

Niko Linzer, Alexis Trumbull, Rukiye Nar, Matthew D. Gibbons, David T. Yu, John Strouboulis, Jörg Bungert

Original languageEnglish
Article number681550
JournalFrontiers in Molecular Biosciences
Volume8
DOIs
Published13 May 2021

Bibliographical note

Funding Information: This work was funded by a grant from the American Society of Hematology and by matching funds from the UF College of Medicine (JB). Publisher Copyright: © Copyright © 2021 Linzer, Trumbull, Nar, Gibbons, Yu, Strouboulis and Bungert. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

King's Authors

Abstract

Transcription by RNA polymerase II (Pol II) is regulated by different processes, including alterations in chromatin structure, interactions between distal regulatory elements and promoters, formation of transcription domains enriched for Pol II and co-regulators, and mechanisms involved in the initiation, elongation, and termination steps of transcription. Transcription factor TFII-I, originally identified as an initiator (INR)-binding protein, contains multiple protein–protein interaction domains and plays diverse roles in the regulation of transcription. Genome-wide analysis revealed that TFII-I associates with expressed as well as repressed genes. Consistently, TFII-I interacts with co-regulators that either positively or negatively regulate the transcription. Furthermore, TFII-I has been shown to regulate transcription pausing by interacting with proteins that promote or inhibit the elongation step of transcription. Changes in TFII-I expression in humans are associated with neurological and immunological diseases as well as cancer. Furthermore, TFII-I is essential for the development of mice and represents a barrier for the induction of pluripotency. Here, we review the known functions of TFII-I related to the regulation of Pol II transcription at the stages of initiation and elongation.

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