Regulation of T &B cell interactions determines the clinical phenotype associated with donor-specific antibodies

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Abstract

The cellular mechanisms that regulate donor specific antibody formation (DSA) and antibody mediated rejection (ABMR) remain unknown. In this issue, Louis and colleagues report that specific T regulatory cell and B regulatory transitional cell subsets are concomitantly diminished in patients with DSA and consequent ABMR and advance alterations in specific cytokines and co-stimulatory molecules as important mechanisms by which these cells may suppress DSA formation and independently, progression to ABMR
Original languageEnglish
Pages (from-to)877-879
Number of pages3
JournalKidney International
Volume101
Issue number5
Early online date20 Apr 2022
DOIs
Publication statusPublished - 20 Apr 2022

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