Regulatory B cells: Development, phenotypes, functions, and role in transplantation

Rowa Y. Alhabbab; Estefanía Nova-Lamperti; Octavio Aravena; Hannah M. Burton; Robert I. Lechler; Anthony Dorling; Giovanna Lombardi

doi:10.1111/imr.12800

Regulatory B cells: Development, phenotypes, functions, and role in transplantation

Rowa Y. Alhabbab^*, Estefanía Nova-Lamperti, Octavio Aravena, Hannah M. Burton, Robert I. Lechler, Anthony Dorling, Giovanna Lombardi

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

57 Citations (Scopus)

Abstract

The interest in regulatory B cells (Bregs) began in the 1970s with the evidence that B cells could downregulate the immune system by the production of “inhibitory” antibodies. Subsequently, a series of results from different studies have emphasized that B cells have antibody-independent immunoregulatory functions. Since then, different subsets of B cells with regulatory functions and their development and mechanisms of action have been identified both in human and in animal models of inflammation, transplantation, and autoimmunity. The present review outlines the suggested pathways by which Bregs develop, describes the different subsets of Bregs with their phenotypes and function as well as their role in transplantation, highlighting the differences between human and animal studies throughout.

Original language	English
Pages (from-to)	164-179
Number of pages	16
Journal	Immunological Reviews
Volume	292
Issue number	1
DOIs	https://doi.org/10.1111/imr.12800
Publication status	Published - 1 Nov 2019

Keywords

B-cell development
clinical transplantation
regulatory B cell function
regulatory B-cell subtypes

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10.1111/imr.12800

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abstract = "The interest in regulatory B cells (Bregs) began in the 1970s with the evidence that B cells could downregulate the immune system by the production of “inhibitory” antibodies. Subsequently, a series of results from different studies have emphasized that B cells have antibody-independent immunoregulatory functions. Since then, different subsets of B cells with regulatory functions and their development and mechanisms of action have been identified both in human and in animal models of inflammation, transplantation, and autoimmunity. The present review outlines the suggested pathways by which Bregs develop, describes the different subsets of Bregs with their phenotypes and function as well as their role in transplantation, highlighting the differences between human and animal studies throughout.",

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AU - Nova-Lamperti, Estefanía

AU - Aravena, Octavio

AU - Burton, Hannah M.

AU - Lechler, Robert I.

AU - Dorling, Anthony

AU - Lombardi, Giovanna

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Regulatory B cells: Development, phenotypes, functions, and role in transplantation

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Keywords

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