Regulatory T-cell therapy in Crohn's disease: challenges and advances

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The prevalence of IBD is rising in the Western world. Despite an increasing repertoire of therapeutic targets, a significant proportion of patients suffer chronic morbidity. Studies in mice and humans have highlighted the critical role of regulatory T cells in immune homeostasis, with defects in number and suppressive function of regulatory T cells seen in patients with Crohn's disease. We review the function of regulatory T cells and the pathways by which they exert immune tolerance in the intestinal mucosa. We explore the principles and challenges of manufacturing a cell therapy, and discuss clinical trial evidence to date for their safety and efficacy in human disease, with particular focus on the development of a regulatory T-cell therapy for Crohn's disease.

Original languageEnglish
Pages (from-to)942-952
Number of pages11
Issue number5
Publication statusPublished - 1 May 2020


  • Crohn's disease
  • T lymphocytes
  • immunology
  • immunoregulation
  • intestinal T cells


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