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Regulatory T Cell-Derived Exosomes: Possible Therapeutic and Diagnostic Tools in Transplantation

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Regulatory T Cell-Derived Exosomes : Possible Therapeutic and Diagnostic Tools in Transplantation. / Agarwal, Akansha; Fanelli, Giorgia; Letizia, Marilena; Tung, Sim Lai; Boardman, Dominic; Lechler, Robert; Lombardi, Giovanna; Smyth, Lesley A.

In: Frontiers in immunology, Vol. 5, 555, 11.2014.

Research output: Contribution to journalArticle

Harvard

Agarwal, A, Fanelli, G, Letizia, M, Tung, SL, Boardman, D, Lechler, R, Lombardi, G & Smyth, LA 2014, 'Regulatory T Cell-Derived Exosomes: Possible Therapeutic and Diagnostic Tools in Transplantation', Frontiers in immunology, vol. 5, 555. https://doi.org/10.3389/fimmu.2014.00555

APA

Agarwal, A., Fanelli, G., Letizia, M., Tung, S. L., Boardman, D., Lechler, R., ... Smyth, L. A. (2014). Regulatory T Cell-Derived Exosomes: Possible Therapeutic and Diagnostic Tools in Transplantation. Frontiers in immunology, 5, [555]. https://doi.org/10.3389/fimmu.2014.00555

Vancouver

Agarwal A, Fanelli G, Letizia M, Tung SL, Boardman D, Lechler R et al. Regulatory T Cell-Derived Exosomes: Possible Therapeutic and Diagnostic Tools in Transplantation. Frontiers in immunology. 2014 Nov;5. 555. https://doi.org/10.3389/fimmu.2014.00555

Author

Agarwal, Akansha ; Fanelli, Giorgia ; Letizia, Marilena ; Tung, Sim Lai ; Boardman, Dominic ; Lechler, Robert ; Lombardi, Giovanna ; Smyth, Lesley A. / Regulatory T Cell-Derived Exosomes : Possible Therapeutic and Diagnostic Tools in Transplantation. In: Frontiers in immunology. 2014 ; Vol. 5.

Bibtex Download

@article{057812e69edf401d87352521de2a62d8,
title = "Regulatory T Cell-Derived Exosomes: Possible Therapeutic and Diagnostic Tools in Transplantation",
abstract = "Exosomes are extracellular vesicles released by many cells of the body. These small vesicles play an important part in intercellular communication both in the local environment and systemically, facilitating in the transfer of proteins, cytokines as well as miRNA between cells. The observation that exosomes isolated from immune cells such as dendritic cells (DCs) modulate the immune response has paved the way for these structures to be considered as potential immunotherapeutic reagents. Indeed, clinical trials using DC derived exosomes to facilitate immune responses to specific cancer antigens are now underway. Exosomes can also have a negative effect on the immune response and exosomes isolated from regulatory T cells (Tregs) and other subsets of T cells have been shown to have immune suppressive capacities. Here, we review what is currently known about Treg derived exosomes and their contribution to immune regulation, as well as highlighting their possible therapeutic potential for preventing graft rejection, and use as diagnostic tools to assess transplant outcome.",
author = "Akansha Agarwal and Giorgia Fanelli and Marilena Letizia and Tung, {Sim Lai} and Dominic Boardman and Robert Lechler and Giovanna Lombardi and Smyth, {Lesley A}",
year = "2014",
month = "11",
doi = "10.3389/fimmu.2014.00555",
language = "English",
volume = "5",
journal = "Frontiers in immunology",
issn = "1664-3224",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Regulatory T Cell-Derived Exosomes

T2 - Possible Therapeutic and Diagnostic Tools in Transplantation

AU - Agarwal, Akansha

AU - Fanelli, Giorgia

AU - Letizia, Marilena

AU - Tung, Sim Lai

AU - Boardman, Dominic

AU - Lechler, Robert

AU - Lombardi, Giovanna

AU - Smyth, Lesley A

PY - 2014/11

Y1 - 2014/11

N2 - Exosomes are extracellular vesicles released by many cells of the body. These small vesicles play an important part in intercellular communication both in the local environment and systemically, facilitating in the transfer of proteins, cytokines as well as miRNA between cells. The observation that exosomes isolated from immune cells such as dendritic cells (DCs) modulate the immune response has paved the way for these structures to be considered as potential immunotherapeutic reagents. Indeed, clinical trials using DC derived exosomes to facilitate immune responses to specific cancer antigens are now underway. Exosomes can also have a negative effect on the immune response and exosomes isolated from regulatory T cells (Tregs) and other subsets of T cells have been shown to have immune suppressive capacities. Here, we review what is currently known about Treg derived exosomes and their contribution to immune regulation, as well as highlighting their possible therapeutic potential for preventing graft rejection, and use as diagnostic tools to assess transplant outcome.

AB - Exosomes are extracellular vesicles released by many cells of the body. These small vesicles play an important part in intercellular communication both in the local environment and systemically, facilitating in the transfer of proteins, cytokines as well as miRNA between cells. The observation that exosomes isolated from immune cells such as dendritic cells (DCs) modulate the immune response has paved the way for these structures to be considered as potential immunotherapeutic reagents. Indeed, clinical trials using DC derived exosomes to facilitate immune responses to specific cancer antigens are now underway. Exosomes can also have a negative effect on the immune response and exosomes isolated from regulatory T cells (Tregs) and other subsets of T cells have been shown to have immune suppressive capacities. Here, we review what is currently known about Treg derived exosomes and their contribution to immune regulation, as well as highlighting their possible therapeutic potential for preventing graft rejection, and use as diagnostic tools to assess transplant outcome.

U2 - 10.3389/fimmu.2014.00555

DO - 10.3389/fimmu.2014.00555

M3 - Article

C2 - 25414702

VL - 5

JO - Frontiers in immunology

JF - Frontiers in immunology

SN - 1664-3224

M1 - 555

ER -

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