Regulatory T cells, inflammation and the allergic response-The role of glucocorticoids and Vitamin D

Sarah Dimeloe, Alexandra Nanzer, Kimuli Ryanna, Catherine Hawrylowicz

    Research output: Contribution to journalLiterature reviewpeer-review

    124 Citations (Scopus)

    Abstract

    Regulatory T cells (TRegs) play a central role in the maintenance of peripheral tolerance. They prevent inappropriate immune responses to ubiquitous allergens in healthy individuals, and contribute to the maintenance of immune homeostasis in the airways. Both Foxp3+ and IL-10+ TReg have been implicated in these functions. Glucocorticoids represent the mainstay of treatment for asthma and other allergic conditions, and evidence that steroids influence TReg function will be reviewed. Growing bodies of epidemiological and immunological data suggest a role for endogenous Vitamin D in immune regulation. This review will discuss the role of glucocorticoids and Vitamin D, and their potential interactions in promoting tolerance in the context of allergic disease and asthma. (C) 2010 Elsevier Ltd. All rights reserved.
    Original languageEnglish
    Pages (from-to)86 - 95
    Number of pages10
    JournalJournal of Steroid Biochemistry and Molecular Biology
    Volume120
    Issue number2-3
    DOIs
    Publication statusPublished - May 2010

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