TY - JOUR
T1 - Regulatory T lymphocytes in myocardial infarction
T2 - A promising new therapeutic target
AU - Wang, Ya Ping
AU - Xie, Yao
AU - Ma, Hong
AU - Su, Sheng An
AU - Wang, Yi Dong
AU - Wang, Jian An
AU - Xiang, Mei Xiang
PY - 2016/1/15
Y1 - 2016/1/15
N2 - Myocardial infarction (MI) is one of the leading causes of death especially in developed countries. Although the advent of early myocardial reperfusion therapy contributes to decreasing the mortality of patients with MI, cardiac ischemia-reperfusion injury and adverse remodeling during the repair process still remain the major factors impairing cardiac function and resulting in unsatisfactory prognosis. Excessive inflammation and immune responses play a crucial role during the whole process of MI. Regulatory T lymphocytes, characterized by immunosuppressive capacity, are associated with many immune-related diseases. Recent studies have proven a protective role of regulatory T cells in MI, which is mainly achieved by modulating inflammation and immune responses. In this review, we will summarize current knowledge of regulatory T lymphocytes, and highlight their roles in the onset of MI, ischemia-reperfusion injury, as well as post-infarct cardiac healing and remodeling.
AB - Myocardial infarction (MI) is one of the leading causes of death especially in developed countries. Although the advent of early myocardial reperfusion therapy contributes to decreasing the mortality of patients with MI, cardiac ischemia-reperfusion injury and adverse remodeling during the repair process still remain the major factors impairing cardiac function and resulting in unsatisfactory prognosis. Excessive inflammation and immune responses play a crucial role during the whole process of MI. Regulatory T lymphocytes, characterized by immunosuppressive capacity, are associated with many immune-related diseases. Recent studies have proven a protective role of regulatory T cells in MI, which is mainly achieved by modulating inflammation and immune responses. In this review, we will summarize current knowledge of regulatory T lymphocytes, and highlight their roles in the onset of MI, ischemia-reperfusion injury, as well as post-infarct cardiac healing and remodeling.
KW - Ischemia-reperfusion injury
KW - Myocardial infarction
KW - Plaque instability
KW - Regulatory T lymphocyte
KW - Ventricular remodeling
UR - http://www.scopus.com/inward/record.url?scp=84952845521&partnerID=8YFLogxK
U2 - 10.1016/j.ijcard.2015.11.078
DO - 10.1016/j.ijcard.2015.11.078
M3 - Literature review
AN - SCOPUS:84952845521
SN - 0167-5273
VL - 203
SP - 923
EP - 928
JO - International Journal of Cardiology
JF - International Journal of Cardiology
ER -
