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Regulatory T-cell therapy in Crohn's disease: challenges and advances

Research output: Contribution to journalReview article

Original languageEnglish
Pages (from-to)942-952
Number of pages11
JournalGut
Volume69
Issue number5
DOIs
Published1 May 2020

King's Authors

Abstract

The prevalence of IBD is rising in the Western world. Despite an increasing repertoire of therapeutic targets, a significant proportion of patients suffer chronic morbidity. Studies in mice and humans have highlighted the critical role of regulatory T cells in immune homeostasis, with defects in number and suppressive function of regulatory T cells seen in patients with Crohn's disease. We review the function of regulatory T cells and the pathways by which they exert immune tolerance in the intestinal mucosa. We explore the principles and challenges of manufacturing a cell therapy, and discuss clinical trial evidence to date for their safety and efficacy in human disease, with particular focus on the development of a regulatory T-cell therapy for Crohn's disease.

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