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Relation between clinical risk factors, early cortical changes, and neurodevelopmental outcome in preterm infants

Research output: Contribution to journalArticle

Karina J. Kersbergen, François Leroy, Ivana Išgum, Floris Groenendaal, Linda S. de Vries, Nathalie H.P. Claessens, Ingrid C. van Haastert, Pim Moeskops, Clara Fischer, Jean-François Mangin, Max A. Viergever, Jessica Dubois, Manon J.N.L. Benders

Original languageEnglish
Early online date6 Jul 2016
Publication statusE-pub ahead of print - 6 Jul 2016


  • Relation between clinical risk_KERSBERGEN_Accepted 5Jul2016_GREEN AAM

    Relation_between_clinical_risk_KERSBERGEN_Accepted_5Jul2016_GREEN_AAM.pdf, 828 KB, application/pdf


    Accepted author manuscript


    © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license

King's Authors


Cortical folding mainly takes place in the third trimester of pregnancy and may therefore be influenced by preterm birth. The aim of this study was to evaluate the development of specific cortical structures between early age (around 30 weeks postmenstrual age) and term-equivalent age (TEA, around 40 weeks postmenstrual age) in 71 extremely preterm infants, and to associate this to clinical characteristics and neurodevelopmental outcome at two years of age. First, analysis showed that the central sulcus (CS), lateral fissure (LF) and insula (INS) were present at early MRI in all infants, whereas the other sulci (post-central sulcus [PCS], superior temporal sulcus [STS], superior [SFS] and inferior [IFS] frontal sulcus) were only seen in part of the infants. Relative growth from early to TEA examination was largest in the SFS. A rightward asymmetry of the surface area was seen in development between both examinations except for the LF, which showed a leftward asymmetry at both time points. Second, lower birth weight z-score, multiple pregnancy and prolonged mechanical ventilation showed negative effects on cortical folding of the CS, LF, INS, STS and PCS, mainly on the first examination, suggesting that sulci developing the earliest were the most affected by clinical factors. Finally, in this cohort, a clear association between cortical folding and neurodevelopmental outcome at two years corrected age was found, particularly for receptive language.

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