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Relationship between faecal microbiota and plasma metabolome in rats fed NK603 and MON810 GM maize from the GMO90+ study

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Relationship between faecal microbiota and plasma metabolome in rats fed NK603 and MON810 GM maize from the GMO90+ study. / Mesnage, Robin; Le Roy, Caroline I.; Biserni, Martina; Salles, Bernard; Antoniou, Michael N.

In: Food and Chemical Toxicology, Vol. 131, 110547, 09.2019.

Research output: Contribution to journalArticle

Harvard

Mesnage, R, Le Roy, CI, Biserni, M, Salles, B & Antoniou, MN 2019, 'Relationship between faecal microbiota and plasma metabolome in rats fed NK603 and MON810 GM maize from the GMO90+ study', Food and Chemical Toxicology, vol. 131, 110547. https://doi.org/10.1016/j.fct.2019.05.055

APA

Mesnage, R., Le Roy, C. I., Biserni, M., Salles, B., & Antoniou, M. N. (2019). Relationship between faecal microbiota and plasma metabolome in rats fed NK603 and MON810 GM maize from the GMO90+ study. Food and Chemical Toxicology, 131, [110547]. https://doi.org/10.1016/j.fct.2019.05.055

Vancouver

Mesnage R, Le Roy CI, Biserni M, Salles B, Antoniou MN. Relationship between faecal microbiota and plasma metabolome in rats fed NK603 and MON810 GM maize from the GMO90+ study. Food and Chemical Toxicology. 2019 Sep;131. 110547. https://doi.org/10.1016/j.fct.2019.05.055

Author

Mesnage, Robin ; Le Roy, Caroline I. ; Biserni, Martina ; Salles, Bernard ; Antoniou, Michael N. / Relationship between faecal microbiota and plasma metabolome in rats fed NK603 and MON810 GM maize from the GMO90+ study. In: Food and Chemical Toxicology. 2019 ; Vol. 131.

Bibtex Download

@article{4a38f1b26f774004ae6845b4f243560c,
title = "Relationship between faecal microbiota and plasma metabolome in rats fed NK603 and MON810 GM maize from the GMO90+ study",
abstract = "Safety concerns arising from the consumption of foods derived from genetically modified (GM) crops remains a controversial subject. We report here a faecal microbiota compositional analysis in Wistar rats from the GMO90 + study, which fed glyphosate-tolerant NK603 (+/− Roundup application) and Bt toxin MON810 GM maize for 6 months in comparison to their closest non-GM isogenic lines. We first integrated the faecal microbiota compositional data with results from plasma metabolomics to understand which bacterial species can influence host metabolism. Coriobacteriaceae and Acetatifactor significantly predicted plasma metabolic profile in males, while Bifidobacterium and Ruminococcus were able to predict female plasma metabolites. We then investigated the differences in fecal microbiota composition between group of rats fed MON810 or NK603 GM maize in comparison to their isogenic lines. Bacterial community richness was not altered by the test diets. There were no statistically significant differences in taxa abundance in the rat faecal microbiota that we could attribute to the consumption of either MON810 or NK603. We show that the consumption of the widely cultivated GM maize varieties NK603 and MON810 even up to 33% of the total diet had no effect on the status of the faecal microbiota compared to non-GM near isogenic lines.",
keywords = "Glyphosate, GMO, Metabolite, Microbiome, MON 810, NK603",
author = "Robin Mesnage and {Le Roy}, {Caroline I.} and Martina Biserni and Bernard Salles and Antoniou, {Michael N.}",
year = "2019",
month = sep,
doi = "10.1016/j.fct.2019.05.055",
language = "English",
volume = "131",
journal = "Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association",
issn = "0278-6915",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Relationship between faecal microbiota and plasma metabolome in rats fed NK603 and MON810 GM maize from the GMO90+ study

AU - Mesnage, Robin

AU - Le Roy, Caroline I.

AU - Biserni, Martina

AU - Salles, Bernard

AU - Antoniou, Michael N.

PY - 2019/9

Y1 - 2019/9

N2 - Safety concerns arising from the consumption of foods derived from genetically modified (GM) crops remains a controversial subject. We report here a faecal microbiota compositional analysis in Wistar rats from the GMO90 + study, which fed glyphosate-tolerant NK603 (+/− Roundup application) and Bt toxin MON810 GM maize for 6 months in comparison to their closest non-GM isogenic lines. We first integrated the faecal microbiota compositional data with results from plasma metabolomics to understand which bacterial species can influence host metabolism. Coriobacteriaceae and Acetatifactor significantly predicted plasma metabolic profile in males, while Bifidobacterium and Ruminococcus were able to predict female plasma metabolites. We then investigated the differences in fecal microbiota composition between group of rats fed MON810 or NK603 GM maize in comparison to their isogenic lines. Bacterial community richness was not altered by the test diets. There were no statistically significant differences in taxa abundance in the rat faecal microbiota that we could attribute to the consumption of either MON810 or NK603. We show that the consumption of the widely cultivated GM maize varieties NK603 and MON810 even up to 33% of the total diet had no effect on the status of the faecal microbiota compared to non-GM near isogenic lines.

AB - Safety concerns arising from the consumption of foods derived from genetically modified (GM) crops remains a controversial subject. We report here a faecal microbiota compositional analysis in Wistar rats from the GMO90 + study, which fed glyphosate-tolerant NK603 (+/− Roundup application) and Bt toxin MON810 GM maize for 6 months in comparison to their closest non-GM isogenic lines. We first integrated the faecal microbiota compositional data with results from plasma metabolomics to understand which bacterial species can influence host metabolism. Coriobacteriaceae and Acetatifactor significantly predicted plasma metabolic profile in males, while Bifidobacterium and Ruminococcus were able to predict female plasma metabolites. We then investigated the differences in fecal microbiota composition between group of rats fed MON810 or NK603 GM maize in comparison to their isogenic lines. Bacterial community richness was not altered by the test diets. There were no statistically significant differences in taxa abundance in the rat faecal microbiota that we could attribute to the consumption of either MON810 or NK603. We show that the consumption of the widely cultivated GM maize varieties NK603 and MON810 even up to 33% of the total diet had no effect on the status of the faecal microbiota compared to non-GM near isogenic lines.

KW - Glyphosate

KW - GMO

KW - Metabolite

KW - Microbiome

KW - MON 810

KW - NK603

UR - http://www.scopus.com/inward/record.url?scp=85066924097&partnerID=8YFLogxK

U2 - 10.1016/j.fct.2019.05.055

DO - 10.1016/j.fct.2019.05.055

M3 - Article

AN - SCOPUS:85066924097

VL - 131

JO - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

SN - 0278-6915

M1 - 110547

ER -

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