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Relationship between vectorcardiographic QRSarea, myocardial scar quantification, and response to Cardiac Resynchronization Therapy: Vectorcardiography and cardiac magnetic resonance imaging defined scar

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Uyen Nguyen, Simon Claridge, Kevin Vernooy, Elien Engels, Reza Razavi, Christopher Aldo Rinaldi, Zhong Chen, Frits Prinzen

Original languageEnglish
JournalJournal of Electrocardiology
Early online date8 Feb 2018
Accepted/In press24 Jan 2018
E-pub ahead of print8 Feb 2018


King's Authors


Purpose: To investigate the relationship between vectorcardiography (VCG) and myocardial scar on cardiac magnetic resonance (CMR) imaging, and whether combining these metrics may improve cardiac resynchronization therapy (CRT) response prediction.
Methods: Thirty-three CRT patients were included. QRSarea, Tarea and QRSTarea were derived from the ECG-synthesized VCG. CMR parameters reflecting focal scar core (Scar2SD, Gray2SD) and diffuse fibrosis (pre-T1, extracellular volume [ECV]) were assessed. CRT response was defined as ≥15% reduction in left ventricular end-systolic volume after six months’ follow-up.
Results: VCG QRSarea, Tarea and QRSTarea inversely correlated with focal scar (R=-0.44–-0.58 for Scar2SD, p≤0.010), but not with diffuse fibrosis. Scar2SD, Gray2SD and QRSarea predicted CRT response with AUCs of 0.692 (p=0.063), 0.759 (p=0.012) and 0.737 (p=0.022) respectively. A combined ROC-derived threshold for Scar2SD and QRSarea resulted in 92% CRT response rate for patients with large QRSarea and small Scar2SD or Gray2SD.
Conclusion: Incremental predictive value for CRT response is achieved by a combined CMR-QRSarea analysis.

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