Relationships between airborne pollutants, serum albumin adducts and short-term health outcomes in an experimental crossover study

TY - JOUR

T1 - Relationships between airborne pollutants, serum albumin adducts and short-term health outcomes in an experimental crossover study

AU - Dagnino, Sonia

AU - van Veldhoven, Karin

AU - Barratt, Benjamin

AU - Liu, Sa

AU - Grigoryan, Hasmik

AU - Rappaport, Stephen M

AU - Chung, Kian Fan

AU - Cullinan, Paul

AU - Sinharay, Rudy

AU - Chadeau-Hyam, Marc

AU - Vineis, Paolo

N1 - Copyright © 2019. Published by Elsevier Ltd.

PY - 2019/8/24

Y1 - 2019/8/24

N2 - Exposure to air pollution can have both short-term and long-term effects on health. However, the relationships between specific pollutants and their effects can be obscured by characteristics of both the pollution and the exposed population. One way of elucidating the relationships is to link exposures and internal changes at the level of the individual. To this end, we combined personal exposure monitoring (59 individuals, Oxford Street II crossover study) with mass-spectrometry-based analyses of putative serum albumin adducts (fixed-step selected reaction monitoring). We attempted to infer adducts' identities using data from another, higher-resolution mass spectrometry method, and were able to detect a semi-synthetic standard with both methods. A generalised least squares regression method was used to test for associations between amounts of adducts and pollution measures (ambient concentrations of nitrogen dioxide and particulate matter), and between amounts of adducts and short-term health outcomes (measures of lung health and arterial stiffness). Amounts of some putative adducts (e.g., one with a positive mass shift of ∼143 Da) were associated with exposure to pollution (11 associations), and amounts of other adducts were associated with health outcomes (eight associations). Adducts did not appear to provide a link between exposures and short-term health outcomes.

AB - Exposure to air pollution can have both short-term and long-term effects on health. However, the relationships between specific pollutants and their effects can be obscured by characteristics of both the pollution and the exposed population. One way of elucidating the relationships is to link exposures and internal changes at the level of the individual. To this end, we combined personal exposure monitoring (59 individuals, Oxford Street II crossover study) with mass-spectrometry-based analyses of putative serum albumin adducts (fixed-step selected reaction monitoring). We attempted to infer adducts' identities using data from another, higher-resolution mass spectrometry method, and were able to detect a semi-synthetic standard with both methods. A generalised least squares regression method was used to test for associations between amounts of adducts and pollution measures (ambient concentrations of nitrogen dioxide and particulate matter), and between amounts of adducts and short-term health outcomes (measures of lung health and arterial stiffness). Amounts of some putative adducts (e.g., one with a positive mass shift of ∼143 Da) were associated with exposure to pollution (11 associations), and amounts of other adducts were associated with health outcomes (eight associations). Adducts did not appear to provide a link between exposures and short-term health outcomes.

KW - Adductomics

KW - Air pollution

KW - Albumin

KW - Exposome

UR - http://www.scopus.com/inward/record.url?scp=85071719875&partnerID=8YFLogxK

U2 - 10.1016/j.chemosphere.2019.124667

DO - 10.1016/j.chemosphere.2019.124667

M3 - Article

C2 - 31499299

SN - 0045-6535

VL - 239

SP - 124667

JO - Chemosphere

JF - Chemosphere

M1 - 124667

ER -