TY - JOUR
T1 - Relative pressure estimation from velocity measurements in blood flows
T2 - State-of-the-art and new approaches
AU - Bertoglio, Cristóbal
AU - Nuñez, Rodolfo
AU - Galarce, Felipe
AU - Nordsletten, David
AU - Osses, Axel
PY - 2017/11/9
Y1 - 2017/11/9
N2 - The relative pressure difference across stenotic blood vessels serves as an important clinical index for the diagnosis of many cardiovascular diseases. While the clinical gold standard for relative pressure difference measurements is invasive catheterization, Phase-Contrast Magnetic Resonance Imaging has emerged as a promising tool for enabling a noninvasive quantification, by linking highly spatially resolved velocity measurements with relative pressures via the incompressible Navier-Stokes equations. In this work, we provide a review and analysis of current methods for relative pressure estimation and propose 3 additional techniques. Methods are compared using synthetic data from numerical examples, and sensitivity to subsampling and noise was explored. Through our analysis, we verify that the newly proposed approaches are more robust with respect to spatial subsampling and less sensitive to noise and therefore provide improved means for estimating relative pressure differences noninvasively.
AB - The relative pressure difference across stenotic blood vessels serves as an important clinical index for the diagnosis of many cardiovascular diseases. While the clinical gold standard for relative pressure difference measurements is invasive catheterization, Phase-Contrast Magnetic Resonance Imaging has emerged as a promising tool for enabling a noninvasive quantification, by linking highly spatially resolved velocity measurements with relative pressures via the incompressible Navier-Stokes equations. In this work, we provide a review and analysis of current methods for relative pressure estimation and propose 3 additional techniques. Methods are compared using synthetic data from numerical examples, and sensitivity to subsampling and noise was explored. Through our analysis, we verify that the newly proposed approaches are more robust with respect to spatial subsampling and less sensitive to noise and therefore provide improved means for estimating relative pressure differences noninvasively.
KW - Blood flows
KW - Navier-Stokes equations
KW - Phase-contrast MRI
KW - Relative pressure estimation
UR - http://www.scopus.com/inward/record.url?scp=85033448818&partnerID=8YFLogxK
U2 - 10.1002/cnm.2925
DO - 10.1002/cnm.2925
M3 - Article
AN - SCOPUS:85033448818
SN - 2040-7939
JO - International Journal For Numerical Methods In Biomedical Engineering
JF - International Journal For Numerical Methods In Biomedical Engineering
ER -
