Relative pressure estimation from velocity measurements in blood flows: State-of-the-art and new approaches

TY - JOUR

T1 - Relative pressure estimation from velocity measurements in blood flows

T2 - State-of-the-art and new approaches

AU - Bertoglio, Cristóbal

AU - Nuñez, Rodolfo

AU - Galarce, Felipe

AU - Nordsletten, David

AU - Osses, Axel

PY - 2017/11/9

Y1 - 2017/11/9

N2 - The relative pressure difference across stenotic blood vessels serves as an important clinical index for the diagnosis of many cardiovascular diseases. While the clinical gold standard for relative pressure difference measurements is invasive catheterization, Phase-Contrast Magnetic Resonance Imaging has emerged as a promising tool for enabling a noninvasive quantification, by linking highly spatially resolved velocity measurements with relative pressures via the incompressible Navier-Stokes equations. In this work, we provide a review and analysis of current methods for relative pressure estimation and propose 3 additional techniques. Methods are compared using synthetic data from numerical examples, and sensitivity to subsampling and noise was explored. Through our analysis, we verify that the newly proposed approaches are more robust with respect to spatial subsampling and less sensitive to noise and therefore provide improved means for estimating relative pressure differences noninvasively.

AB - The relative pressure difference across stenotic blood vessels serves as an important clinical index for the diagnosis of many cardiovascular diseases. While the clinical gold standard for relative pressure difference measurements is invasive catheterization, Phase-Contrast Magnetic Resonance Imaging has emerged as a promising tool for enabling a noninvasive quantification, by linking highly spatially resolved velocity measurements with relative pressures via the incompressible Navier-Stokes equations. In this work, we provide a review and analysis of current methods for relative pressure estimation and propose 3 additional techniques. Methods are compared using synthetic data from numerical examples, and sensitivity to subsampling and noise was explored. Through our analysis, we verify that the newly proposed approaches are more robust with respect to spatial subsampling and less sensitive to noise and therefore provide improved means for estimating relative pressure differences noninvasively.

KW - Blood flows

KW - Navier-Stokes equations

KW - Phase-contrast MRI

KW - Relative pressure estimation

UR - https://www.scopus.com/pages/publications/85033448818

U2 - 10.1002/cnm.2925

DO - 10.1002/cnm.2925

M3 - Article

AN - SCOPUS:85033448818

SN - 2040-7939

JO - International Journal For Numerical Methods In Biomedical Engineering

JF - International Journal For Numerical Methods In Biomedical Engineering

ER -