Renal Allograft Recipients Fail to Increase Interferon-gamma During Invasive Fungal Diseases

D. Armstrong-James; I. Teo; S. Herbst; M. Petrou; K. Y. Shiu; A. McLean; D. Taube; A. Dorling; S. Shaunak

doi:10.1111/j.1600-6143.2012.04254.x

Renal Allograft Recipients Fail to Increase Interferon-gamma During Invasive Fungal Diseases

D. Armstrong-James
, I. Teo
, S. Herbst
, M. Petrou
, K. Y. Shiu
, A. McLean
, D. Taube
, A. Dorling
, S. Shaunak

Baylor College of Medicine
Imperial College London

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Invasive fungal diseases are a major cause of death in renal allograft recipients. We previously reported that adjunctive recombinant human interferon-? therapy has clinical utility for invasive fungal diseases after renal transplantation. We have now developed a rapid peripheral blood-based quantitative real-time PCR assay that enables accurate profiling of cytokine imbalances. Our preliminary studies in renal transplant patients with invasive fungal diseases suggest that they fail to mount an adequate interferon-? response to the fungal infection. In addition, they have reduced IL-10 and increased TNF-a when compared to stable renal transplant patients. These preliminary cytokine profiling-based observations provide a possible explanation for the therapeutic benefit of adjunctive human interferon-? therapy in renal allograft recipients with invasive fungal diseases.

Original language	English
Pages (from-to)	3437-3440
Number of pages	4
Journal	American Journal of Transplantation
Volume	12
Issue number	12
Early online date	13 Sept 2012
DOIs	https://doi.org/10.1111/j.1600-6143.2012.04254.x
Publication status	Published - Dec 2012

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10.1111/j.1600-6143.2012.04254.x

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title = "Renal Allograft Recipients Fail to Increase Interferon-gamma During Invasive Fungal Diseases",

abstract = "Invasive fungal diseases are a major cause of death in renal allograft recipients. We previously reported that adjunctive recombinant human interferon-? therapy has clinical utility for invasive fungal diseases after renal transplantation. We have now developed a rapid peripheral blood-based quantitative real-time PCR assay that enables accurate profiling of cytokine imbalances. Our preliminary studies in renal transplant patients with invasive fungal diseases suggest that they fail to mount an adequate interferon-? response to the fungal infection. In addition, they have reduced IL-10 and increased TNF-a when compared to stable renal transplant patients. These preliminary cytokine profiling-based observations provide a possible explanation for the therapeutic benefit of adjunctive human interferon-? therapy in renal allograft recipients with invasive fungal diseases.",

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AU - Armstrong-James, D.

AU - Teo, I.

AU - Herbst, S.

AU - Petrou, M.

AU - Shiu, K. Y.

AU - McLean, A.

AU - Taube, D.

AU - Dorling, A.

AU - Shaunak, S.

PY - 2012/12

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N2 - Invasive fungal diseases are a major cause of death in renal allograft recipients. We previously reported that adjunctive recombinant human interferon-? therapy has clinical utility for invasive fungal diseases after renal transplantation. We have now developed a rapid peripheral blood-based quantitative real-time PCR assay that enables accurate profiling of cytokine imbalances. Our preliminary studies in renal transplant patients with invasive fungal diseases suggest that they fail to mount an adequate interferon-? response to the fungal infection. In addition, they have reduced IL-10 and increased TNF-a when compared to stable renal transplant patients. These preliminary cytokine profiling-based observations provide a possible explanation for the therapeutic benefit of adjunctive human interferon-? therapy in renal allograft recipients with invasive fungal diseases.

AB - Invasive fungal diseases are a major cause of death in renal allograft recipients. We previously reported that adjunctive recombinant human interferon-? therapy has clinical utility for invasive fungal diseases after renal transplantation. We have now developed a rapid peripheral blood-based quantitative real-time PCR assay that enables accurate profiling of cytokine imbalances. Our preliminary studies in renal transplant patients with invasive fungal diseases suggest that they fail to mount an adequate interferon-? response to the fungal infection. In addition, they have reduced IL-10 and increased TNF-a when compared to stable renal transplant patients. These preliminary cytokine profiling-based observations provide a possible explanation for the therapeutic benefit of adjunctive human interferon-? therapy in renal allograft recipients with invasive fungal diseases.

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DO - 10.1111/j.1600-6143.2012.04254.x

M3 - Article

SN - 1600-6135

VL - 12

SP - 3437

EP - 3440

JO - American Journal of Transplantation

JF - American Journal of Transplantation

IS - 12

ER -

Renal Allograft Recipients Fail to Increase Interferon-gamma During Invasive Fungal Diseases

Abstract

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