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Renal Allograft Recipients Fail to Increase Interferon-gamma During Invasive Fungal Diseases

Research output: Contribution to journalArticle

D. Armstrong-James, I. Teo, S. Herbst, M. Petrou, K. Y. Shiu, A. McLean, D. Taube, A. Dorling, S. Shaunak

Original languageEnglish
Pages (from-to)3437-3440
Number of pages4
JournalAmerican Journal of Transplantation
Volume12
Issue number12
Early online date13 Sep 2012
DOIs
Publication statusPublished - Dec 2012

King's Authors

Abstract

Invasive fungal diseases are a major cause of death in renal allograft recipients. We previously reported that adjunctive recombinant human interferon-? therapy has clinical utility for invasive fungal diseases after renal transplantation. We have now developed a rapid peripheral blood-based quantitative real-time PCR assay that enables accurate profiling of cytokine imbalances. Our preliminary studies in renal transplant patients with invasive fungal diseases suggest that they fail to mount an adequate interferon-? response to the fungal infection. In addition, they have reduced IL-10 and increased TNF-a when compared to stable renal transplant patients. These preliminary cytokine profiling-based observations provide a possible explanation for the therapeutic benefit of adjunctive human interferon-? therapy in renal allograft recipients with invasive fungal diseases.

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