Renal iron load in sickle cell disease is influenced by severity of haemolysis

Nisha Vasavda, Lucía Gutiérrez, Michael J House, Emma Drasar, Tim G St Pierre, Swee L Thein

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    22 Citations (Scopus)


    Spin density projection-assisted R2-magnetic resonance imaging (R2-MRI; FerriScan(®)) scans from 40 chelation-naïve sickle cell patients were used to assess renal iron load by measuring renal R2 (R-R2). Clinical data were collected retrospectively for the 2-year period preceding the scan. R-R2 showed no significant correlation with transfusional iron load (assessed by liver iron concentration), but correlated significantly with serum bilirubin (R = 0·61, P <0·0001) and lactate dehydrogenase (R = 0·58, P <0·0001). Mean (±standard deviation) R-R2 was higher (P = 0·02) in patients with renal hyperfiltration (29·8 ± 10·3/s) than those without (23·11 ± 6·6/s). Five patients had significantly lower signal intensity in the renal cortex, as compared to the medulla. These patients had a significantly higher (P <0·0001) mean R-R2 than those showing no cortico-medullary difference. We postulate that the increased R-R2 is associated with haemolysis rather than transfusional iron load in sickle cell disease.
    Original languageEnglish
    Pages (from-to)599-605
    Number of pages7
    JournalBritish Journal of Haematology
    Issue number5
    Publication statusPublished - Jun 2012


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