Renal Transplantation

Ben Afzali; Kerem Atalar; Refik Gokmen; David J A Goldsmith

doi:10.1007/978-1-84882-704-2_14

Renal Transplantation

Ben Afzali, Kerem Atalar, Refik Gokmen, David J A Goldsmith

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Citation (Scopus)

Abstract

Transplantation is a remarkable story of the successful fusion of medical and surgical expertise that has revolutionized the lives of patients and is now the treatment of choice for most patients with end-organ diseases. While current immunosuppressive modalities have significantly reduced the likelihood of transplant loss from acute rejection (routine transplant survival in most centers is now greater than 90% by the end of the first postoperative year), the complications of long-term broad-spectrum immunosuppression still carry significant morbidity and mortality, and necessitate stringent posttransplant surveillance and reduction of long-term risk. The induction of a state of immunological tolerance to transplanted organs without the requirement of pharmacological immunosuppression and with retention of the capacity to respond to infectious agents remains the long-term goal of the transplant team.

Original language	English
Title of host publication	Medical Therapy in Urology
Editors	Iqbal Shergill, Manit Arya, Philippe R Grange, AR Mundy
Publisher	Springer
Pages	197-208
ISBN (Electronic)	978-1-84882-704-2
ISBN (Print)	978-1-84882-703-5
DOIs	https://doi.org/10.1007/978-1-84882-704-2_14
Publication status	Published - 2010

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10.1007/978-1-84882-704-2_14

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title = "Renal Transplantation",

abstract = "Transplantation is a remarkable story of the successful fusion of medical and surgical expertise that has revolutionized the lives of patients and is now the treatment of choice for most patients with end-organ diseases. While current immunosuppressive modalities have significantly reduced the likelihood of transplant loss from acute rejection (routine transplant survival in most centers is now greater than 90% by the end of the first postoperative year), the complications of long-term broad-spectrum immunosuppression still carry significant morbidity and mortality, and necessitate stringent posttransplant surveillance and reduction of long-term risk. The induction of a state of immunological tolerance to transplanted organs without the requirement of pharmacological immunosuppression and with retention of the capacity to respond to infectious agents remains the long-term goal of the transplant team.",

author = "Ben Afzali and Kerem Atalar and Refik Gokmen and Goldsmith, {David J A}",

year = "2010",

doi = "10.1007/978-1-84882-704-2_14",

language = "English",

isbn = "978-1-84882-703-5",

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TY - CHAP

T1 - Renal Transplantation

AU - Afzali, Ben

AU - Atalar, Kerem

AU - Gokmen, Refik

AU - Goldsmith, David J A

PY - 2010

Y1 - 2010

N2 - Transplantation is a remarkable story of the successful fusion of medical and surgical expertise that has revolutionized the lives of patients and is now the treatment of choice for most patients with end-organ diseases. While current immunosuppressive modalities have significantly reduced the likelihood of transplant loss from acute rejection (routine transplant survival in most centers is now greater than 90% by the end of the first postoperative year), the complications of long-term broad-spectrum immunosuppression still carry significant morbidity and mortality, and necessitate stringent posttransplant surveillance and reduction of long-term risk. The induction of a state of immunological tolerance to transplanted organs without the requirement of pharmacological immunosuppression and with retention of the capacity to respond to infectious agents remains the long-term goal of the transplant team.

AB - Transplantation is a remarkable story of the successful fusion of medical and surgical expertise that has revolutionized the lives of patients and is now the treatment of choice for most patients with end-organ diseases. While current immunosuppressive modalities have significantly reduced the likelihood of transplant loss from acute rejection (routine transplant survival in most centers is now greater than 90% by the end of the first postoperative year), the complications of long-term broad-spectrum immunosuppression still carry significant morbidity and mortality, and necessitate stringent posttransplant surveillance and reduction of long-term risk. The induction of a state of immunological tolerance to transplanted organs without the requirement of pharmacological immunosuppression and with retention of the capacity to respond to infectious agents remains the long-term goal of the transplant team.

U2 - 10.1007/978-1-84882-704-2_14

DO - 10.1007/978-1-84882-704-2_14

M3 - Chapter

SN - 978-1-84882-703-5

SP - 197

EP - 208

BT - Medical Therapy in Urology

A2 - Shergill, Iqbal

A2 - Arya, Manit

A2 - Grange, Philippe R

A2 - Mundy, AR

PB - Springer

ER -

Renal Transplantation

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