King's College London

Research portal

Repeated lipopolysaccharide exposure modifies immune and sickness behaviour response in an animal model of chronic inflammation

Research output: Contribution to journalArticle

Standard

Repeated lipopolysaccharide exposure modifies immune and sickness behaviour response in an animal model of chronic inflammation. / Musaelyan, Ksenia; Aldridge, S. E.; Du Preez, Andrea; Egeland, Martin Tor Lutzhoft; Zunszain, Patricia Ana; Pariante, Carmine Maria; Thuret, Sandrine; Fernandes, Catherine.

In: Journal of Psychopharmacology, Vol. 32, No. 2, 08.11.2017, p. 236-247.

Research output: Contribution to journalArticle

Harvard

Musaelyan, K, Aldridge, SE, Du Preez, A, Egeland, MTL, Zunszain, PA, Pariante, CM, Thuret, S & Fernandes, C 2017, 'Repeated lipopolysaccharide exposure modifies immune and sickness behaviour response in an animal model of chronic inflammation', Journal of Psychopharmacology, vol. 32, no. 2, pp. 236-247. https://doi.org/10.1177/0269881117746902

APA

Musaelyan, K., Aldridge, S. E., Du Preez, A., Egeland, M. T. L., Zunszain, P. A., Pariante, C. M., Thuret, S., & Fernandes, C. (Accepted/In press). Repeated lipopolysaccharide exposure modifies immune and sickness behaviour response in an animal model of chronic inflammation. Journal of Psychopharmacology, 32(2), 236-247. https://doi.org/10.1177/0269881117746902

Vancouver

Musaelyan K, Aldridge SE, Du Preez A, Egeland MTL, Zunszain PA, Pariante CM et al. Repeated lipopolysaccharide exposure modifies immune and sickness behaviour response in an animal model of chronic inflammation. Journal of Psychopharmacology. 2017 Nov 8;32(2):236-247. https://doi.org/10.1177/0269881117746902

Author

Musaelyan, Ksenia ; Aldridge, S. E. ; Du Preez, Andrea ; Egeland, Martin Tor Lutzhoft ; Zunszain, Patricia Ana ; Pariante, Carmine Maria ; Thuret, Sandrine ; Fernandes, Catherine. / Repeated lipopolysaccharide exposure modifies immune and sickness behaviour response in an animal model of chronic inflammation. In: Journal of Psychopharmacology. 2017 ; Vol. 32, No. 2. pp. 236-247.

Bibtex Download

@article{4e06ffee67ea4b5f947e5c277795f67a,
title = "Repeated lipopolysaccharide exposure modifies immune and sickness behaviour response in an animal model of chronic inflammation",
abstract = "Repeated lipopolysaccharide (LPS) exposure is often used in longitudinal preclinical models of depression. However, the potential phenotypic differences from acute depression-mimicking effects are rarely described. This study compared chronic LPS administration of doses previously used in depression research to a new mode of escalating dose injections. Adult male BALB/c mice (n=8/group) were injected intraperitoneally with either a single 0.83 mg/kg dose, a repeated 0.1 mg/kg LPS dose or a dose which escalated weekly from 0.33 to 0.83 mg/kg LPS for six weeks. The escalating LPS group demonstrated most features of sickness behaviour such as weight loss and reduction in food intake every week, whist this effect was not sustained in other groups. Moreover, only in the escalating LPS group did most peripheral plasma cytokines levels, measured using Luminex{\textregistered} multiplex technology, such as interleukin 6 (IL-6), tumor necrosis factor α and IL-2 remain over 3 fold elevated on the 6th week. In addition, exposure to escalating doses led to a reduction of neuroblast maturation in the dentate gyrus relevant for depression neurobiology. Therefore, this mode of injections might be useful in the studies attempting to replicate neurobiological aspects of the chronic inflammatory state observed in mood disorders.",
keywords = "Lipopolysaccharide, chronic inflammation, sickness behaviour, adult neurogenesis, hippocampus, cytokine, microglia",
author = "Ksenia Musaelyan and Aldridge, {S. E.} and {Du Preez}, Andrea and Egeland, {Martin Tor Lutzhoft} and Zunszain, {Patricia Ana} and Pariante, {Carmine Maria} and Sandrine Thuret and Catherine Fernandes",
year = "2017",
month = nov,
day = "8",
doi = "10.1177/0269881117746902",
language = "English",
volume = "32",
pages = "236--247",
journal = "Journal of Psychopharmacology",
issn = "0269-8811",
publisher = "SAGE Publications Ltd STM",
number = "2",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Repeated lipopolysaccharide exposure modifies immune and sickness behaviour response in an animal model of chronic inflammation

AU - Musaelyan, Ksenia

AU - Aldridge, S. E.

AU - Du Preez, Andrea

AU - Egeland, Martin Tor Lutzhoft

AU - Zunszain, Patricia Ana

AU - Pariante, Carmine Maria

AU - Thuret, Sandrine

AU - Fernandes, Catherine

PY - 2017/11/8

Y1 - 2017/11/8

N2 - Repeated lipopolysaccharide (LPS) exposure is often used in longitudinal preclinical models of depression. However, the potential phenotypic differences from acute depression-mimicking effects are rarely described. This study compared chronic LPS administration of doses previously used in depression research to a new mode of escalating dose injections. Adult male BALB/c mice (n=8/group) were injected intraperitoneally with either a single 0.83 mg/kg dose, a repeated 0.1 mg/kg LPS dose or a dose which escalated weekly from 0.33 to 0.83 mg/kg LPS for six weeks. The escalating LPS group demonstrated most features of sickness behaviour such as weight loss and reduction in food intake every week, whist this effect was not sustained in other groups. Moreover, only in the escalating LPS group did most peripheral plasma cytokines levels, measured using Luminex® multiplex technology, such as interleukin 6 (IL-6), tumor necrosis factor α and IL-2 remain over 3 fold elevated on the 6th week. In addition, exposure to escalating doses led to a reduction of neuroblast maturation in the dentate gyrus relevant for depression neurobiology. Therefore, this mode of injections might be useful in the studies attempting to replicate neurobiological aspects of the chronic inflammatory state observed in mood disorders.

AB - Repeated lipopolysaccharide (LPS) exposure is often used in longitudinal preclinical models of depression. However, the potential phenotypic differences from acute depression-mimicking effects are rarely described. This study compared chronic LPS administration of doses previously used in depression research to a new mode of escalating dose injections. Adult male BALB/c mice (n=8/group) were injected intraperitoneally with either a single 0.83 mg/kg dose, a repeated 0.1 mg/kg LPS dose or a dose which escalated weekly from 0.33 to 0.83 mg/kg LPS for six weeks. The escalating LPS group demonstrated most features of sickness behaviour such as weight loss and reduction in food intake every week, whist this effect was not sustained in other groups. Moreover, only in the escalating LPS group did most peripheral plasma cytokines levels, measured using Luminex® multiplex technology, such as interleukin 6 (IL-6), tumor necrosis factor α and IL-2 remain over 3 fold elevated on the 6th week. In addition, exposure to escalating doses led to a reduction of neuroblast maturation in the dentate gyrus relevant for depression neurobiology. Therefore, this mode of injections might be useful in the studies attempting to replicate neurobiological aspects of the chronic inflammatory state observed in mood disorders.

KW - Lipopolysaccharide, chronic inflammation, sickness behaviour, adult neurogenesis, hippocampus, cytokine, microglia

U2 - 10.1177/0269881117746902

DO - 10.1177/0269881117746902

M3 - Article

VL - 32

SP - 236

EP - 247

JO - Journal of Psychopharmacology

JF - Journal of Psychopharmacology

SN - 0269-8811

IS - 2

ER -

View graph of relations

© 2018 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454