King's College London

Odevixibat treatment in progressive familial intrahepatic cholestasis: a randomised, placebo-controlled, phase 3 trial

Thompson, R. J., Arnell, H., Artan, R., Baumann, U., Calvo, P. L., Czubkowski, P., Dalgic, B., D'Antiga, L., Durmaz, Ö., Fischler, B., Gonzalès, E., Grammatikopoulos, T., Gupte, G., Hardikar, W., Houwen, R. H. J., Kamath, B. M., Karpen, S. J., Kjems, L., Lacaille, F., Lachaux, A., & 14 othersLainka, E., Mack, C. L., Mattsson, J. P., McKiernan, P., Özen, H., Rajwal, S. R., Roquelaure, B., Shagrani, M., Shteyer, E., Soufi, N., Sturm, E., Tessier, M. E., Verkade, H. J. & Horn, P., 1 Jul 2022, (E-pub ahead of print) In: The Lancet Gastroenterology & Hepatology.

Research output: Contribution to journal › Article › peer-review

Liver Disease and Risk of Hepatocellular Carcinoma in Children With Mutations in TALDO1

University of Washington Center for Mendelian Genomics, 22 Oct 2021, (E-pub ahead of print) In: Hepatology Communications.

Research output: Contribution to journal › Article › peer-review

Study of acute liver failure in children using next generation sequencing technology

Hegarty, R., Thompson, R., Dhawan, A. & Grammatikopoulos, T., 14 May 2021, (Accepted/In press) In: Journal of Pediatrics.

Research output: Contribution to journal › Article › peer-review

Mutations in Myosin 5B in Children With Early-onset Cholestasis

Cockar, I., Foskett, P., Strautnieks, S., Clinch, Y., Fustok, J., Rahman, O., Sutton, H., Mtegha, M., Fessatou, S., Kontaki, E., Papaevangelou, V., Deheragoda, M., Thompson, R. J. & Grammatikopoulos, T., 1 Aug 2020, In: Journal of Pediatric Gastroenterology and Nutrition. 71, 2, p. 184-188 5 p.

Research output: Contribution to journal › Article › peer-review

Genotype correlates with the natural history of severe bile salt export pump deficiency

NAtural course and Prognosis of PFIC and Effect of biliary Diversion (NAPPED) consortium, Jul 2020, In: Journal of Hepatology. 73, 1, p. 84-93 10 p.

Research output: Contribution to journal › Article › peer-review

Clinical phenotype of adult-onset liver disease in patients with variants in ABCB4, ABCB11, and ATP8B1

Nayagam, J. S., Foskett, P., Strautnieks, S., Agarwal, K., Miquel, R., Joshi, D. & Thompson, R. J., Oct 2022, In: Hepatology Communications. 6, 10, p. 2654-2664 11 p.

Research output: Contribution to journal › Article › peer-review

Maralixibat for the treatment of PFIC: Long-term, IBAT inhibition in an open-label, Phase 2 study

Loomes, K. M., Squires, R. H., Kelly, D., Rajwal, S., Soufi, N., Lachaux, A., Jankowska, I., Mack, C., Setchell, K. D. R., Karthikeyan, P., Kennedy, C., Dorenbaum, A., Desai, N. K., Garner, W., Jaecklin, T., Vig, P., Miethke, A. & Thompson, R. J., Sep 2022, In: Hepatology Communications. 6, 9, p. 2379-2390 12 p.

Research output: Contribution to journal › Article › peer-review

Odevixibat treatment in progressive familial intrahepatic cholestasis: a randomised, placebo-controlled, phase 3 trial

Thompson, R. J., Arnell, H., Artan, R., Baumann, U., Calvo, P. L., Czubkowski, P., Dalgic, B., D'Antiga, L., Durmaz, Ö., Fischler, B., Gonzalès, E., Grammatikopoulos, T., Gupte, G., Hardikar, W., Houwen, R. H. J., Kamath, B. M., Karpen, S. J., Kjems, L., Lacaille, F., Lachaux, A., & 14 othersLainka, E., Mack, C. L., Mattsson, J. P., McKiernan, P., Özen, H., Rajwal, S. R., Roquelaure, B., Shagrani, M., Shteyer, E., Soufi, N., Sturm, E., Tessier, M. E., Verkade, H. J. & Horn, P., 1 Jul 2022, (E-pub ahead of print) In: The Lancet Gastroenterology & Hepatology.

Research output: Contribution to journal › Article › peer-review

Outbreak of hepatitis in children: clinical course of children with acute liver failure admitted to the intensive care unit

Deep, A., Grammatikopoulos, T., Heaton, N., Verma, A. & Dhawan, A., Jul 2022, In: Intensive Care Medicine. 48, 7, p. 958-962 5 p.

Research output: Contribution to journal › Letter › peer-review

Human iPSC-derived hepatocyte system models cholestasis with tight junction protein 2 deficiency

Li, C. Z., Ogawa, H., Ng, S. S., Chen, X., Kishimoto, E., Sakabe, K., Fukami, A., Hu, Y. C., Mayhew, C. N., Hellmann, J., Miethke, A., Tasnova, N. L., Blackford, S. J. I., Tang, Z. M., Syanda, A. M., Ma, L., Xiao, F., Sambrotta, M., Tavabie, O., Soares, F., & 6 othersBaker, O., Danovi, D., Hayashi, H., Thompson, R. J., Rashid, S. T. & Asai, A., Apr 2022, In: JHEP Reports. 4, 4, 100446.

Research output: Contribution to journal › Article › peer-review

Immunometabolic profiling of ascites from patients with acute-on-chronic liver failure reveals increased MerTK plus immunosuppressive myeloid cells and cell death markers with preferential lipid metabolism compared to cirrhosis without organ failure

Singanayagam, A., Erminelli, D., Triantafyllou, E., Bernsmeier, C., Tunc, E., Krasniqi, M., Patel, V., Lebosse, F., Nathwani, R., Atkinson, A., Dhar, A., Heneghan, M., Auzinger, G., Khamri, W., Adams, D., Wendon, J., Thursz, M., McPhail, M. J. W. & Antoniades, H., Apr 2019, In: Journal of Hepatology. 70, p. E183-E183

Research output: Contribution to journal › Meeting Abstract › peer-review

Serum bile acid profiles distinguish severe alcoholic hepatitis from decompensated alcohol-related cirrhosis

Tyson, L. D., Atkinson, S., Pechlivanis, A., Holmes, E., Vergis, N., Nathwani, R., Maurice, J., Taylor-Robinson, S., Mullish, B. H., Williams, R., McPhail, M. J. W., Patel, V. & Thursz, M., Apr 2019, In: Journal of Hepatology. 70, p. E108-E108

Research output: Contribution to journal › Meeting Abstract › peer-review

Hemorrhagic and thrombotic complications in critically patients with cirrhosis

Ow, T-W., Fatourou, E., Rabinowich, L., Roberts, L., Williams, R., Auzinger, G., McPhail, M. J. W., Wendon, J. & Bernal, W., Apr 2019, In: Journal of Hepatology. 70, p. E173-E173

Research output: Contribution to journal › Meeting Abstract › peer-review

PD-1+monocytes and macrophages contribute to impaired microbial clearance following acute liver failure

Triantafyllou, E., Gudd, C., Nathwani, R., Trovato, F., Possamai, L., Morrison, R., Bernsmeier, C., Patel, V., Khamri, W., Goldin, R., Wendon, J., McPhail, M., Woollard, K., Thursz, M. & Antoniades, C., Apr 2019, In: Journal of Hepatology. 70, p. E430-E431

Research output: Contribution to journal › Meeting Abstract › peer-review

Improved stratification of liver failure syndromes using broad-panel bile acid LCMS phenotyping demonstrates novel pathways of dysregulation in tertiary bile acids in acute-on-chronic liver failure

Wolfer, K., Lewis, M., Sarafian, M., Taylor, D. R., Vincent, R., Patel, V. C. & McPhail, M. J. W., Apr 2019, In: Journal of Hepatology. 70, p. E184-E185

Research output: Contribution to journal › Meeting Abstract › peer-review