Reporting standards for studies of diagnostic test accuracy in dementia: The STARDdem Initiative

Anna H. Noel-Storr; Jenny M. McCleery; Edo Richard; Craig W. Ritchie; Leon Flicker; Sarah J. Cullum; Daniel Davis; Terence J. Quinn; Chris Hyde; Anne W. S. Rutjes; Nadja Smailagic; Sue Marcus; Sandra Black; Kaj Blennow; Carol Brayne; Mario Fiorivanti; Julene K. Johnson; Sascha Koepke; Lon S. Schneider; Andrew Simmons; Niklas Mattsson; Henrik Zetterberg; Patrick M. M. Bossuyt; Gordon Wilcock; Rupert McShane

doi:10.1212/WNL.0000000000000621

Reporting standards for studies of diagnostic test accuracy in dementia: The STARDdem Initiative

Anna H. Noel-Storr, Jenny M. McCleery, Edo Richard, Craig W. Ritchie, Leon Flicker, Sarah J. Cullum, Daniel Davis, Terence J. Quinn, Chris Hyde, Anne W. S. Rutjes, Nadja Smailagic, Sue Marcus, Sandra Black, Kaj Blennow, Carol Brayne, Mario Fiorivanti, Julene K. Johnson, Sascha Koepke, Lon S. Schneider, Andrew SimmonsNiklas Mattsson, Henrik Zetterberg, Patrick M. M. Bossuyt, Gordon Wilcock, Rupert McShane^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

159 Citations (Scopus)

Abstract

Objective: To provide guidance on standards for reporting studies of diagnostic test accuracy for dementia disorders.

Methods: An international consensus process on reporting standards in dementia and cognitive impairment (STARDdem) was established, focusing on studies presenting data from which sensitivity and specificity were reported or could be derived. A working group led the initiative through 4 rounds of consensus work, using a modified Delphi process and culminating in a face-to-face consensus meeting in October 2012. The aim of this process was to agree on how best to supplement the generic standards of the STARD statement to enhance their utility and encourage their use in dementia research.

Results: More than 200 comments were received during the wider consultation rounds. The areas at most risk of inadequate reporting were identified and a set of dementia-specific recommendations to supplement the STARD guidance were developed, including better reporting of patient selection, the reference standard used, avoidance of circularity, and reporting of test-retest reliability.

Conclusion: STARDdem is an implementation of the STARD statement in which the original checklist is elaborated and supplemented with guidance pertinent to studies of cognitive disorders. Its adoption is expected to increase transparency, enable more effective evaluation of diagnostic tests in Alzheimer disease and dementia, contribute to greater adherence to methodologic standards, and advance the development of Alzheimer biomarkers.

Original language	English
Pages (from-to)	364-373
Number of pages	10
Journal	Neurology
Volume	83
Issue number	4
DOIs	https://doi.org/10.1212/WNL.0000000000000621
Publication status	Published - 22 Jul 2014

Keywords

ALZHEIMERS ASSOCIATION WORKGROUPS
MILD COGNITIVE IMPAIRMENT
NATIONAL INSTITUTE
RANDOMIZED-TRIALS
SPINAL-FLUID
DISEASE
GUIDELINES
RECOMMENDATIONS
BIOMARKERS
QUALITY

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Noel-Storr, A. H., McCleery, J. M., Richard, E., Ritchie, C. W., Flicker, L., Cullum, S. J., Davis, D., Quinn, T. J., Hyde, C., Rutjes, A. W. S., Smailagic, N., Marcus, S., Black, S., Blennow, K., Brayne, C., Fiorivanti, M., Johnson, J. K., Koepke, S., Schneider, L. S., ... McShane, R. (2014). Reporting standards for studies of diagnostic test accuracy in dementia: The STARDdem Initiative. Neurology, 83(4), 364-373. https://doi.org/10.1212/WNL.0000000000000621

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title = "Reporting standards for studies of diagnostic test accuracy in dementia: The STARDdem Initiative",

abstract = "Objective: To provide guidance on standards for reporting studies of diagnostic test accuracy for dementia disorders.Methods: An international consensus process on reporting standards in dementia and cognitive impairment (STARDdem) was established, focusing on studies presenting data from which sensitivity and specificity were reported or could be derived. A working group led the initiative through 4 rounds of consensus work, using a modified Delphi process and culminating in a face-to-face consensus meeting in October 2012. The aim of this process was to agree on how best to supplement the generic standards of the STARD statement to enhance their utility and encourage their use in dementia research.Results: More than 200 comments were received during the wider consultation rounds. The areas at most risk of inadequate reporting were identified and a set of dementia-specific recommendations to supplement the STARD guidance were developed, including better reporting of patient selection, the reference standard used, avoidance of circularity, and reporting of test-retest reliability.Conclusion: STARDdem is an implementation of the STARD statement in which the original checklist is elaborated and supplemented with guidance pertinent to studies of cognitive disorders. Its adoption is expected to increase transparency, enable more effective evaluation of diagnostic tests in Alzheimer disease and dementia, contribute to greater adherence to methodologic standards, and advance the development of Alzheimer biomarkers.",

keywords = "ALZHEIMERS ASSOCIATION WORKGROUPS, MILD COGNITIVE IMPAIRMENT, NATIONAL INSTITUTE, RANDOMIZED-TRIALS, SPINAL-FLUID, DISEASE, GUIDELINES, RECOMMENDATIONS, BIOMARKERS, QUALITY",

author = "Noel-Storr, {Anna H.} and McCleery, {Jenny M.} and Edo Richard and Ritchie, {Craig W.} and Leon Flicker and Cullum, {Sarah J.} and Daniel Davis and Quinn, {Terence J.} and Chris Hyde and Rutjes, {Anne W. S.} and Nadja Smailagic and Sue Marcus and Sandra Black and Kaj Blennow and Carol Brayne and Mario Fiorivanti and Johnson, {Julene K.} and Sascha Koepke and Schneider, {Lon S.} and Andrew Simmons and Niklas Mattsson and Henrik Zetterberg and Bossuyt, {Patrick M. M.} and Gordon Wilcock and Rupert McShane",

year = "2014",

month = jul,

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doi = "10.1212/WNL.0000000000000621",

language = "English",

volume = "83",

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Noel-Storr, AH, McCleery, JM, Richard, E, Ritchie, CW, Flicker, L, Cullum, SJ, Davis, D, Quinn, TJ, Hyde, C, Rutjes, AWS, Smailagic, N, Marcus, S, Black, S, Blennow, K, Brayne, C, Fiorivanti, M, Johnson, JK, Koepke, S, Schneider, LS, Simmons, A, Mattsson, N, Zetterberg, H, Bossuyt, PMM, Wilcock, G & McShane, R 2014, 'Reporting standards for studies of diagnostic test accuracy in dementia: The STARDdem Initiative', Neurology, vol. 83, no. 4, pp. 364-373. https://doi.org/10.1212/WNL.0000000000000621

TY - JOUR

T1 - Reporting standards for studies of diagnostic test accuracy in dementia

T2 - The STARDdem Initiative

AU - Noel-Storr, Anna H.

AU - McCleery, Jenny M.

AU - Richard, Edo

AU - Ritchie, Craig W.

AU - Flicker, Leon

AU - Cullum, Sarah J.

AU - Davis, Daniel

AU - Quinn, Terence J.

AU - Hyde, Chris

AU - Rutjes, Anne W. S.

AU - Smailagic, Nadja

AU - Marcus, Sue

AU - Black, Sandra

AU - Blennow, Kaj

AU - Brayne, Carol

AU - Fiorivanti, Mario

AU - Johnson, Julene K.

AU - Koepke, Sascha

AU - Schneider, Lon S.

AU - Simmons, Andrew

AU - Mattsson, Niklas

AU - Zetterberg, Henrik

AU - Bossuyt, Patrick M. M.

AU - Wilcock, Gordon

AU - McShane, Rupert

PY - 2014/7/22

Y1 - 2014/7/22

N2 - Objective: To provide guidance on standards for reporting studies of diagnostic test accuracy for dementia disorders.Methods: An international consensus process on reporting standards in dementia and cognitive impairment (STARDdem) was established, focusing on studies presenting data from which sensitivity and specificity were reported or could be derived. A working group led the initiative through 4 rounds of consensus work, using a modified Delphi process and culminating in a face-to-face consensus meeting in October 2012. The aim of this process was to agree on how best to supplement the generic standards of the STARD statement to enhance their utility and encourage their use in dementia research.Results: More than 200 comments were received during the wider consultation rounds. The areas at most risk of inadequate reporting were identified and a set of dementia-specific recommendations to supplement the STARD guidance were developed, including better reporting of patient selection, the reference standard used, avoidance of circularity, and reporting of test-retest reliability.Conclusion: STARDdem is an implementation of the STARD statement in which the original checklist is elaborated and supplemented with guidance pertinent to studies of cognitive disorders. Its adoption is expected to increase transparency, enable more effective evaluation of diagnostic tests in Alzheimer disease and dementia, contribute to greater adherence to methodologic standards, and advance the development of Alzheimer biomarkers.

AB - Objective: To provide guidance on standards for reporting studies of diagnostic test accuracy for dementia disorders.Methods: An international consensus process on reporting standards in dementia and cognitive impairment (STARDdem) was established, focusing on studies presenting data from which sensitivity and specificity were reported or could be derived. A working group led the initiative through 4 rounds of consensus work, using a modified Delphi process and culminating in a face-to-face consensus meeting in October 2012. The aim of this process was to agree on how best to supplement the generic standards of the STARD statement to enhance their utility and encourage their use in dementia research.Results: More than 200 comments were received during the wider consultation rounds. The areas at most risk of inadequate reporting were identified and a set of dementia-specific recommendations to supplement the STARD guidance were developed, including better reporting of patient selection, the reference standard used, avoidance of circularity, and reporting of test-retest reliability.Conclusion: STARDdem is an implementation of the STARD statement in which the original checklist is elaborated and supplemented with guidance pertinent to studies of cognitive disorders. Its adoption is expected to increase transparency, enable more effective evaluation of diagnostic tests in Alzheimer disease and dementia, contribute to greater adherence to methodologic standards, and advance the development of Alzheimer biomarkers.

KW - ALZHEIMERS ASSOCIATION WORKGROUPS

KW - MILD COGNITIVE IMPAIRMENT

KW - NATIONAL INSTITUTE

KW - RANDOMIZED-TRIALS

KW - SPINAL-FLUID

KW - DISEASE

KW - GUIDELINES

KW - RECOMMENDATIONS

KW - BIOMARKERS

KW - QUALITY

U2 - 10.1212/WNL.0000000000000621

DO - 10.1212/WNL.0000000000000621

M3 - Article

SN - 0028-3878

VL - 83

SP - 364

EP - 373

JO - Neurology

JF - Neurology

IS - 4

ER -

Reporting standards for studies of diagnostic test accuracy in dementia: The STARDdem Initiative

Abstract

Keywords

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