Reprogramming towards Endothelial Cells for Vascular Regeneration

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Abstract

Abstract Endothelial damage and dysfunction are implicated in cardiovascular pathological changes and the development of vascular diseases. In view of the fact that the spontaneous endothelial cell (EC) regeneration is a slow and insufficient process, it would be of great significance to explore alternative cell sources capable of generating functional ECs to repair damaged endothelium. Indeed, recent achievements of cell reprogramming to convert somatic cells to other cell types provide new powerful approaches to study endothelial regeneration. Based on progress in the research field, the present review aims to explore the strategies and mechanisms of generating endothelial cells through reprogramming from somatic cells, and to examine what this means for the potential application of cell therapy in the clinic.
Original languageEnglish
JournalGenes & Diseases
Early online date27 Feb 2016
DOIs
Publication statusE-pub ahead of print - 27 Feb 2016

Keywords

  • Stem cells
  • cell reprogramming
  • endothelial cells
  • iPS cells
  • endothelial regeneration
  • atherosclerosis

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