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Reprogramming towards Endothelial Cells for Vascular Regeneration

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
JournalGenes & Diseases
Early online date27 Feb 2016
DOIs
Accepted/In press11 Feb 2016
E-pub ahead of print27 Feb 2016

Documents

  • 1-s2.0-S2352304216000180-main

    1_s2.0_S2352304216000180_main.pdf, 1.91 MB, application/pdf

    Uploaded date:29 Feb 2016

    Version:Accepted author manuscript

    Licence:CC BY-NC-ND

King's Authors

Abstract

Abstract Endothelial damage and dysfunction are implicated in cardiovascular pathological changes and the development of vascular diseases. In view of the fact that the spontaneous endothelial cell (EC) regeneration is a slow and insufficient process, it would be of great significance to explore alternative cell sources capable of generating functional ECs to repair damaged endothelium. Indeed, recent achievements of cell reprogramming to convert somatic cells to other cell types provide new powerful approaches to study endothelial regeneration. Based on progress in the research field, the present review aims to explore the strategies and mechanisms of generating endothelial cells through reprogramming from somatic cells, and to examine what this means for the potential application of cell therapy in the clinic.

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