Requirement for leptin in the induction and progression of autoimmune encephalomyelitis

G Matarese; A Di Giacomo; V Sanna; G  M Lord; J  K Howard; A Di Tuoro; S  R Bloom; R  I Lechler; S Zappacosta; S Fontana

Requirement for leptin in the induction and progression of autoimmune encephalomyelitis

G Matarese, A Di Giacomo, V Sanna, G M Lord, J K Howard, A Di Tuoro, S R Bloom, R I Lechler, S Zappacosta, S Fontana

Nutritional Sciences

Research output: Contribution to journal › Article › peer-review

310 Citations (Scopus)

Abstract

Recent evidence indicates that leptin modifies T cell immunity, and may provide a key link between nutritional deficiency and immune dysfunction. To study the influence of leptin on autoimmunity, susceptibility to experimental autoimmune encephalomyelitis induced by immunization with a myelin-derived peptide was examined in leptin-deficient, C57BL/6J-ob/ob mice, with or without leptin replacement, and in wild-type controls. Leptin replacement converted disease resistance to susceptibility in the C57BL/6J-ob/ob mice; this was accompanied by a switch from a Th2 to Th1 pattern of cytokine release and consequent reversal of Ig subclass production. Our findings suggest that leptin is required for the induction and maintenance of an effective proinflammatory immune response in the CNS.

Original language	English
Pages (from-to)	5909 - 5916
Number of pages	8
Journal	Journal of Immunology
Volume	166
Issue number	10
Publication status	Published - 15 May 2001

Cite this

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title = "Requirement for leptin in the induction and progression of autoimmune encephalomyelitis",

abstract = "Recent evidence indicates that leptin modifies T cell immunity, and may provide a key link between nutritional deficiency and immune dysfunction. To study the influence of leptin on autoimmunity, susceptibility to experimental autoimmune encephalomyelitis induced by immunization with a myelin-derived peptide was examined in leptin-deficient, C57BL/6J-ob/ob mice, with or without leptin replacement, and in wild-type controls. Leptin replacement converted disease resistance to susceptibility in the C57BL/6J-ob/ob mice; this was accompanied by a switch from a Th2 to Th1 pattern of cytokine release and consequent reversal of Ig subclass production. Our findings suggest that leptin is required for the induction and maintenance of an effective proinflammatory immune response in the CNS.",

author = "G Matarese and {Di Giacomo}, A and V Sanna and Lord, {G M} and Howard, {J K} and {Di Tuoro}, A and Bloom, {S R} and Lechler, {R I} and S Zappacosta and S Fontana",

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pages = "5909 -- 5916",

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T1 - Requirement for leptin in the induction and progression of autoimmune encephalomyelitis

AU - Matarese, G

AU - Di Giacomo, A

AU - Sanna, V

AU - Lord, G M

AU - Howard, J K

AU - Di Tuoro, A

AU - Bloom, S R

AU - Lechler, R I

AU - Zappacosta, S

AU - Fontana, S

PY - 2001/5/15

Y1 - 2001/5/15

N2 - Recent evidence indicates that leptin modifies T cell immunity, and may provide a key link between nutritional deficiency and immune dysfunction. To study the influence of leptin on autoimmunity, susceptibility to experimental autoimmune encephalomyelitis induced by immunization with a myelin-derived peptide was examined in leptin-deficient, C57BL/6J-ob/ob mice, with or without leptin replacement, and in wild-type controls. Leptin replacement converted disease resistance to susceptibility in the C57BL/6J-ob/ob mice; this was accompanied by a switch from a Th2 to Th1 pattern of cytokine release and consequent reversal of Ig subclass production. Our findings suggest that leptin is required for the induction and maintenance of an effective proinflammatory immune response in the CNS.

AB - Recent evidence indicates that leptin modifies T cell immunity, and may provide a key link between nutritional deficiency and immune dysfunction. To study the influence of leptin on autoimmunity, susceptibility to experimental autoimmune encephalomyelitis induced by immunization with a myelin-derived peptide was examined in leptin-deficient, C57BL/6J-ob/ob mice, with or without leptin replacement, and in wild-type controls. Leptin replacement converted disease resistance to susceptibility in the C57BL/6J-ob/ob mice; this was accompanied by a switch from a Th2 to Th1 pattern of cytokine release and consequent reversal of Ig subclass production. Our findings suggest that leptin is required for the induction and maintenance of an effective proinflammatory immune response in the CNS.

M3 - Article

SN - 1550-6606

VL - 166

SP - 5909

EP - 5916

JO - Journal of Immunology

JF - Journal of Immunology

IS - 10

ER -

Requirement for leptin in the induction and progression of autoimmune encephalomyelitis

Abstract

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