Resolving dynamic changes in brain metabolism using biosensors and on-line microdialysis

TY - JOUR

T1 - Resolving dynamic changes in brain metabolism using biosensors and on-line microdialysis

AU - Parkin, M C

AU - Hopwood, S E

AU - Boutelle, M G

AU - Strong, A J

PY - 2003/9/1

Y1 - 2003/9/1

N2 - A tight coupling exists in the brain between the activity of neurons, the energetic consequences of this activity and the local blood flow. This makes the monitoring of the levels of energy metabolites, such as glucose and lactate, in the fluid surrounding the neurons a particularly effective means of studying brain function. This review outlines why rapid monitoring of brain metabolism in vivo is effective, and demonstrates how the in vivo techniques of implanted biosensors and on-line microdialysis can be used to study the brain in the laboratory and in brain-injury patients. (C) 2003 Published by Elsevier B.V.

AB - A tight coupling exists in the brain between the activity of neurons, the energetic consequences of this activity and the local blood flow. This makes the monitoring of the levels of energy metabolites, such as glucose and lactate, in the fluid surrounding the neurons a particularly effective means of studying brain function. This review outlines why rapid monitoring of brain metabolism in vivo is effective, and demonstrates how the in vivo techniques of implanted biosensors and on-line microdialysis can be used to study the brain in the laboratory and in brain-injury patients. (C) 2003 Published by Elsevier B.V.

UR - http://www.scopus.com/inward/record.url?scp=0041377768&partnerID=8YFLogxK

U2 - 10.1016/S0165-9936(03)00912-9

DO - 10.1016/S0165-9936(03)00912-9

M3 - Article

VL - 22

SP - 487

EP - 497

JO - TRENDS IN ANALYTICAL CHEMISTRY

JF - TRENDS IN ANALYTICAL CHEMISTRY

IS - 9

T2 - Workshop on Emerging Technologies for the Analysis of Endogenous Biomaterials and Single-Molecule Studies

Y2 - 1 January 2003

ER -