TY - CHAP
T1 - Respiratory Sound Intensity as a Noninvasive Acoustic Biomarker in COPD
AU - Lozano-García, Manuel
AU - Paredes, Francesca Aguilar
AU - Jolley, Caroline J.
AU - Jané, Raimon
N1 - Publisher Copyright:
© 2024 IEEE.
PY - 2024
Y1 - 2024
N2 - Chronic obstructive pulmonary disease (COPD) is a common respiratory disease and a leading cause of death worldwide. Due to the clinical heterogeneity of COPD and the low specificity of the spirometric tests currently used for diagnosing COPD, it is often under-diagnosed. The aim of this work is to explore the potential use of respiratory sound (RS) intensity as a noninvasive acoustic biomarker for the diagnosis and monitoring of COPD. Flow and RS signals were recorded in 15 healthy controls, 7 mild COPD patients, and 5 severe COPD patients, during the performance of a variable inspiratory flow protocol. RS intensity was estimated using fixed sample entropy. RS intensity showed a very strong correlation with respiratory flow in all participants. RS intensity and flow increased similarly during the variable inspiratory flow protocol. However, the increasing pattern of the two measures was different between healthy controls and COPD patients, with lower increases in COPD patients. RS intensity is therefore sensitive to altered respiratory mechanics in COPD and could therefore be used as a noninvasive acoustic biomarker for monitoring COPD patients.
AB - Chronic obstructive pulmonary disease (COPD) is a common respiratory disease and a leading cause of death worldwide. Due to the clinical heterogeneity of COPD and the low specificity of the spirometric tests currently used for diagnosing COPD, it is often under-diagnosed. The aim of this work is to explore the potential use of respiratory sound (RS) intensity as a noninvasive acoustic biomarker for the diagnosis and monitoring of COPD. Flow and RS signals were recorded in 15 healthy controls, 7 mild COPD patients, and 5 severe COPD patients, during the performance of a variable inspiratory flow protocol. RS intensity was estimated using fixed sample entropy. RS intensity showed a very strong correlation with respiratory flow in all participants. RS intensity and flow increased similarly during the variable inspiratory flow protocol. However, the increasing pattern of the two measures was different between healthy controls and COPD patients, with lower increases in COPD patients. RS intensity is therefore sensitive to altered respiratory mechanics in COPD and could therefore be used as a noninvasive acoustic biomarker for monitoring COPD patients.
KW - acoustic biomarker
KW - chronic obstructive pulmonary disease
KW - respiratory sound intensity
UR - http://www.scopus.com/inward/record.url?scp=85214974976&partnerID=8YFLogxK
U2 - 10.1109/EMBC53108.2024.10782895
DO - 10.1109/EMBC53108.2024.10782895
M3 - Conference paper
AN - SCOPUS:85214974976
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
BT - 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2024 - Proceedings
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2024
Y2 - 15 July 2024 through 19 July 2024
ER -
