Respiratory syncytial virus infection and chronic respiratory morbidity - is there a functional or genetic predisposition?

TY - JOUR

T1 - Respiratory syncytial virus infection and chronic respiratory morbidity - is there a functional or genetic predisposition?

AU - Drysdale, Simon B.

AU - Milner, Anthony D.

AU - Greenough, Anne

N1 - © 2012 The Author(s)/Acta Paediatrica © 2012 Foundation Acta Paediatrica.

PY - 2012/11

Y1 - 2012/11

N2 - A systematic literature review has been undertaken. Respiratory syncytial virus (RSV) lower respiratory tract infection (LRTI) in infancy is associated with chronic respiratory morbidity. Premorbid abnormal lung function may predispose to RVS LRTI in prematurely born infants. Conclusion: Single-nucleotide polymorphisms in genes coding for IL-8, IL-19, IL-20, IL-13 mannose-binding lectin, IFNG and a RANTES polymorphism have been associated with subsequent wheeze following RSV LRTI in term-born infants.

AB - A systematic literature review has been undertaken. Respiratory syncytial virus (RSV) lower respiratory tract infection (LRTI) in infancy is associated with chronic respiratory morbidity. Premorbid abnormal lung function may predispose to RVS LRTI in prematurely born infants. Conclusion: Single-nucleotide polymorphisms in genes coding for IL-8, IL-19, IL-20, IL-13 mannose-binding lectin, IFNG and a RANTES polymorphism have been associated with subsequent wheeze following RSV LRTI in term-born infants.

U2 - 10.1111/j.1651-2227.2012.02825.x

DO - 10.1111/j.1651-2227.2012.02825.x

M3 - Literature review

C2 - 22963586

SN - 0803-5253

VL - 101

SP - 1114

EP - 1120

JO - Acta Paediatrica

JF - Acta Paediatrica

IS - 11

ER -