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Respiratory viral infections in infancy and school age respiratory outcomes and healthcare costs

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)342–348
JournalPediatric Pulmonology
Issue number3
Early online date4 Jan 2018
Publication statusPublished - Mar 2018


  • Respiratory viral infections in_MACBEAN_Firstonline4January2018_GREEN AAM

    Respiratory_viral_infections_in_MACBEAN_Firstonline4January2018_GREEN_AAM.pdf, 523 KB, application/pdf


    Accepted author manuscript

    This is the peer reviewed version of the following article: MacBean V, Drysdale SB, Yarzi MN, Peacock JL, Rafferty GF, Greenough A. Respiratory viral infections in infancy and school age respiratory outcomes and healthcare costs. Pediatric Pulmonology. 2018;53:342–348. , which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

  • Respiratory viral infections in_MACBEAN_Firstonline4January2018_Supplementary

    Respiratory_viral_infections_in_MACBEAN_Firstonline4January2018_Supplementary.pdf, 414 KB, application/pdf


    Other version

King's Authors


OBJECTIVES: To determine the impact of viral lower respiratory tract infections (LRTIs) in infancy including rhinovirus (RV) and infancy respiratory syncytial virus (RSV), on school age pulmonary function and healthcare utilization in prematurely born children.

WORKING HYPOTHESIS: School age respiratory outcomes would be worse and healthcare utilization greater in children who had viral LRTIs in infancy.

STUDY DESIGN: Prospective study.

SUBJECT SELECTION: A cohort of prematurely born children who had symptomatic LRTIs during infancy documented, was recalled.

METHODS: Pulmonary function was assessed at 5 to 7 years of age and health related costs of care from aged one to follow-up determined.

RESULTS: Fifty-one children, median gestational age 33+6 weeks, were assessed at a median (IQR) age 7.03 (6.37-7.26) years. Twenty-one children had no LRTI, 14 RV LRTI, 10 RSV LRTI, and 6 another viral LRTI (other LRTI). Compared to the no LRTI group, the RV group had a lower FEV1 (P = 0.033) and the other LRTI group a lower FVC (P = 0.006). Non-respiratory medication costs were higher in the RV (P = 0.018) and RSV (P = 0.013) groups. Overall respiratory healthcare costs in the RV (£153/year) and RSV (£27/year) groups did not differ significantly from the no LRTI group (£56/year); the other LRTI group (£431/year) had higher respiratory healthcare costs (P = 0.042).

CONCLUSIONS: In moderately prematurely born children, RV and RSV LRTIs in infancy were not associated with higher respiratory healthcare costs after infancy. Children who experienced LRTIs caused by other respiratory viruses (including RV) had higher respiratory healthcare costs and greater pulmonary function impairment.

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