Response of circulating tumor cells to systemic therapy in patients with metastatic breast cancer: comparison of quantitative polymerase chain reaction and immunocytochemical techniques

B M Smith, M J Slade, J English, H Graham, Lüchtenborg Lüchtenborg, H D Sinnett, N C Cross, R C Coombes

Research output: Contribution to journalArticlepeer-review

141 Citations (Scopus)

Abstract

We previously developed a quantitative system for the detection of cytokeratin 19 (CK-19) transcripts using reverse transcriptase polymerase chain reaction (PCR) to detect breast carcinoma cells in blood and bone marrow. The aim of this study was to determine the value of this system in monitoring patients with metastatic disease and to compare it with an established immunocytochemical method.
Original languageEnglish
Pages (from-to)1432-1439
Number of pages8
JournalJournal of Clinical Oncology
Volume18
Issue number7
Publication statusPublished - Apr 2000

Fingerprint

Dive into the research topics of 'Response of circulating tumor cells to systemic therapy in patients with metastatic breast cancer: comparison of quantitative polymerase chain reaction and immunocytochemical techniques'. Together they form a unique fingerprint.

Cite this