Response of circulating tumor cells to systemic therapy in patients with metastatic breast cancer: comparison of quantitative polymerase chain reaction and immunocytochemical techniques

B M Smith; M J Slade; J English; H Graham; Lüchtenborg Lüchtenborg; H D Sinnett; N C Cross; R C Coombes

Response of circulating tumor cells to systemic therapy in patients with metastatic breast cancer: comparison of quantitative polymerase chain reaction and immunocytochemical techniques

B M Smith, M J Slade, J English, H Graham, Lüchtenborg Lüchtenborg, H D Sinnett, N C Cross, R C Coombes

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Abstract

We previously developed a quantitative system for the detection of cytokeratin 19 (CK-19) transcripts using reverse transcriptase polymerase chain reaction (PCR) to detect breast carcinoma cells in blood and bone marrow. The aim of this study was to determine the value of this system in monitoring patients with metastatic disease and to compare it with an established immunocytochemical method.

Original language	English
Pages (from-to)	1432-1439
Number of pages	8
Journal	Journal of Clinical Oncology
Volume	18
Issue number	7
Publication status	Published - Apr 2000

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http://jco.ascopubs.org/content/18/7/1432.abstract?sid=3f6757a9-ee98-4a4b-a9e0-d663a739c8c3

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Smith, B. M., Slade, M. J., English, J., Graham, H., Lüchtenborg, L., Sinnett, H. D., Cross, N. C., & Coombes, R. C. (2000). Response of circulating tumor cells to systemic therapy in patients with metastatic breast cancer: comparison of quantitative polymerase chain reaction and immunocytochemical techniques. Journal of Clinical Oncology, 18(7), 1432-1439. http://jco.ascopubs.org/content/18/7/1432.abstract?sid=3f6757a9-ee98-4a4b-a9e0-d663a739c8c3

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title = "Response of circulating tumor cells to systemic therapy in patients with metastatic breast cancer: comparison of quantitative polymerase chain reaction and immunocytochemical techniques",

abstract = "We previously developed a quantitative system for the detection of cytokeratin 19 (CK-19) transcripts using reverse transcriptase polymerase chain reaction (PCR) to detect breast carcinoma cells in blood and bone marrow. The aim of this study was to determine the value of this system in monitoring patients with metastatic disease and to compare it with an established immunocytochemical method.",

author = "Smith, {B M} and Slade, {M J} and J English and H Graham and L{\"u}chtenborg L{\"u}chtenborg and Sinnett, {H D} and Cross, {N C} and Coombes, {R C}",

year = "2000",

month = apr,

language = "English",

volume = "18",

pages = "1432--1439",

journal = "Journal of Clinical Oncology",

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publisher = "American Society of Clinical Oncology",

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Smith, BM, Slade, MJ, English, J, Graham, H , Lüchtenborg, L, Sinnett, HD, Cross, NC & Coombes, RC 2000, 'Response of circulating tumor cells to systemic therapy in patients with metastatic breast cancer: comparison of quantitative polymerase chain reaction and immunocytochemical techniques', Journal of Clinical Oncology, vol. 18, no. 7, pp. 1432-1439. <http://jco.ascopubs.org/content/18/7/1432.abstract?sid=3f6757a9-ee98-4a4b-a9e0-d663a739c8c3>

Response of circulating tumor cells to systemic therapy in patients with metastatic breast cancer: comparison of quantitative polymerase chain reaction and immunocytochemical techniques. / Smith, B M; Slade, M J; English, J et al.
In: Journal of Clinical Oncology, Vol. 18, No. 7, 04.2000, p. 1432-1439.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Response of circulating tumor cells to systemic therapy in patients with metastatic breast cancer

T2 - comparison of quantitative polymerase chain reaction and immunocytochemical techniques

AU - Smith, B M

AU - Slade, M J

AU - English, J

AU - Graham, H

AU - Lüchtenborg, Lüchtenborg

AU - Sinnett, H D

AU - Cross, N C

AU - Coombes, R C

PY - 2000/4

Y1 - 2000/4

N2 - We previously developed a quantitative system for the detection of cytokeratin 19 (CK-19) transcripts using reverse transcriptase polymerase chain reaction (PCR) to detect breast carcinoma cells in blood and bone marrow. The aim of this study was to determine the value of this system in monitoring patients with metastatic disease and to compare it with an established immunocytochemical method.

AB - We previously developed a quantitative system for the detection of cytokeratin 19 (CK-19) transcripts using reverse transcriptase polymerase chain reaction (PCR) to detect breast carcinoma cells in blood and bone marrow. The aim of this study was to determine the value of this system in monitoring patients with metastatic disease and to compare it with an established immunocytochemical method.

M3 - Article

C2 - 10735890

SN - 0732-183X

VL - 18

SP - 1432

EP - 1439

JO - Journal of Clinical Oncology

JF - Journal of Clinical Oncology

IS - 7

ER -

Response of circulating tumor cells to systemic therapy in patients with metastatic breast cancer: comparison of quantitative polymerase chain reaction and immunocytochemical techniques

Abstract

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