Resting-State Neurophysiological Activity Patterns in Young People with ASD, ADHD, and ASD + ADHD

Elizabeth Shephard; Charlotte Tye; Karen L. Ashwood; Bahar Azadi; Philip Asherson; Patrick F. Bolton; Grainne McLoughlin

doi:10.1007/s10803-017-3300-4

Resting-State Neurophysiological Activity Patterns in Young People with ASD, ADHD, and ASD + ADHD

Elizabeth Shephard, Charlotte Tye, Karen L. Ashwood, Bahar Azadi, Philip Asherson, Patrick F. Bolton, Grainne McLoughlin

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Abstract

Altered power of resting-state neurophysiological activity has been associated with autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD), which commonly co-occur. We compared resting-state neurophysiological power in children with ASD, ADHD, co-occurring ASD + ADHD, and typically developing controls. Children with ASD (ASD/ASD + ADHD) showed reduced theta and alpha power compared to children without ASD (controls/ADHD). Children with ADHD (ADHD/ASD + ADHD) displayed decreased delta power compared to children without ADHD (ASD/controls). Children with ASD + ADHD largely presented as an additive co-occurrence with deficits of both disorders, although reduced theta compared to ADHD-only and reduced delta compared to controls suggested some unique markers. Identifying specific neurophysiological profiles in ASD and ADHD may assist in characterising more homogeneous subgroups to inform treatment approaches and aetiological investigations.

Original language	English
Journal	Journal of autism and developmental disorders
Early online date	13 Sept 2017
DOIs	https://doi.org/10.1007/s10803-017-3300-4
Publication status	Published - Jan 2018

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Resting-State Neurophysiological Activity SHEPHARD epub 13Sep2017 GOLD AAM CCBYAccepted author manuscript, 1.18 MBLicence: CC BY

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title = "Resting-State Neurophysiological Activity Patterns in Young People with ASD, ADHD, and ASD + ADHD",

abstract = "Altered power of resting-state neurophysiological activity has been associated with autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD), which commonly co-occur. We compared resting-state neurophysiological power in children with ASD, ADHD, co-occurring ASD + ADHD, and typically developing controls. Children with ASD (ASD/ASD + ADHD) showed reduced theta and alpha power compared to children without ASD (controls/ADHD). Children with ADHD (ADHD/ASD + ADHD) displayed decreased delta power compared to children without ADHD (ASD/controls). Children with ASD + ADHD largely presented as an additive co-occurrence with deficits of both disorders, although reduced theta compared to ADHD-only and reduced delta compared to controls suggested some unique markers. Identifying specific neurophysiological profiles in ASD and ADHD may assist in characterising more homogeneous subgroups to inform treatment approaches and aetiological investigations.",

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AU - Shephard, Elizabeth

AU - Tye, Charlotte

AU - Ashwood, Karen L.

AU - Azadi, Bahar

AU - Asherson, Philip

AU - Bolton, Patrick F.

AU - McLoughlin, Grainne

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N2 - Altered power of resting-state neurophysiological activity has been associated with autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD), which commonly co-occur. We compared resting-state neurophysiological power in children with ASD, ADHD, co-occurring ASD + ADHD, and typically developing controls. Children with ASD (ASD/ASD + ADHD) showed reduced theta and alpha power compared to children without ASD (controls/ADHD). Children with ADHD (ADHD/ASD + ADHD) displayed decreased delta power compared to children without ADHD (ASD/controls). Children with ASD + ADHD largely presented as an additive co-occurrence with deficits of both disorders, although reduced theta compared to ADHD-only and reduced delta compared to controls suggested some unique markers. Identifying specific neurophysiological profiles in ASD and ADHD may assist in characterising more homogeneous subgroups to inform treatment approaches and aetiological investigations.

AB - Altered power of resting-state neurophysiological activity has been associated with autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD), which commonly co-occur. We compared resting-state neurophysiological power in children with ASD, ADHD, co-occurring ASD + ADHD, and typically developing controls. Children with ASD (ASD/ASD + ADHD) showed reduced theta and alpha power compared to children without ASD (controls/ADHD). Children with ADHD (ADHD/ASD + ADHD) displayed decreased delta power compared to children without ADHD (ASD/controls). Children with ASD + ADHD largely presented as an additive co-occurrence with deficits of both disorders, although reduced theta compared to ADHD-only and reduced delta compared to controls suggested some unique markers. Identifying specific neurophysiological profiles in ASD and ADHD may assist in characterising more homogeneous subgroups to inform treatment approaches and aetiological investigations.

U2 - 10.1007/s10803-017-3300-4

DO - 10.1007/s10803-017-3300-4

M3 - Article

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ER -

Resting-State Neurophysiological Activity Patterns in Young People with ASD, ADHD, and ASD + ADHD

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