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Resting-state EEG alpha/theta ratio related to neuropsychological test performance in Parkinson's Disease

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Alberto Jaramillo-Jimenez, Jazmin Ximena Suarez-Revelo, John Fredy Ochoa-Gomez, Jairo Alexander Carmona Arroyave, Yamile Bocanegra, Francisco Lopera, Omar Buriticá, David Antonio Pineda-Salazar, Leonardo Moreno Gómez, Carlos Andrés Tobón Quintero, Miguel Germán Borda, Laura Bonanni, Dominic H. Ffytche, Kolbjørn Brønnick, Dag Aarsland

Original languageEnglish
Pages (from-to)756-764
Number of pages9
JournalClinical Neurophysiology
Volume132
Issue number3
DOIs
PublishedMar 2021

Bibliographical note

Funding Information: This work was supported by the Research Development Committee (CODI) - Universidad de Antioquia (University of Antioquia), Colombia, under the research project: “Procesamiento del lenguaje de acción en pacientes con enfermedad ganglio-basal desde una perspectiva neuropsicológica y neurofisiológica” (grant reference PRG-2014-768). In addition, this paper represents independent research supported by the Norwegian government, through hospital owner Helse Vest (Western Norway Regional Health Authority). Funding Information: We want to thank all the participants, researchers that collaborated (Ana Baena, Paula Andrea Ospina Lopera, Diana Paola Alzate), the Research Development Committee (CODI) at Universidad de Antioquia (University of Antioquia), as well as the staff and facilities provided by Grupo de Neurociencias de Antioquia (GNA), Grupo Neuropsicolog?a y Conducta (GRUNECO), Semillero SINAPSIS and NeuroCo (research incubator programs) and the School of Medicine at the Universidad de Antioquia in Colombia, as well to the Centre for age-related medicine (SESAM) in Norway. This work was supported by the Research Development Committee (CODI) - Universidad de Antioquia (University of Antioquia), Colombia, under the research project: ?Procesamiento del lenguaje de acci?n en pacientes con enfermedad ganglio-basal desde una perspectiva neuropsicol?gica y neurofisiol?gica? (grant reference PRG-2014-768). In addition, this paper represents independent research supported by the Norwegian government, through hospital owner Helse Vest (Western Norway Regional Health Authority). Publisher Copyright: © 2021 International Federation of Clinical Neurophysiology Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

King's Authors

Abstract

Objective: To determine possible associations of hemispheric-regional alpha/theta ratio (α/θ) with neuropsychological test performance in Parkinson's Disease (PD) non-demented patients. Methods: 36 PD were matched to 36 Healthy Controls (HC). The α/θ in eight hemispheric regions was computed from the relative power spectral density of the resting-state quantitative electroencephalogram (qEEG). Correlations between α/θ and performance in several neuropsychological tests were conducted, significant findings were included in a moderation analysis. Results: The α/θ in all regions was lower in PD than in HC, with larger effect sizes in the posterior regions. Right parietal, and right and left occipital α/θ had significant positive correlations with performance in Judgement of Line Orientation Test (JLOT) in PD. Adjusted moderation analysis indicated that right, but not left, occipital α/θ influenced the JLOT performance related to PD. Conclusions: Reduction of the occipital α/θ, in particular on the right side, was associated with visuospatial performance impairment in PD. Significance: Visuospatial impairment in PD, which is highly correlated with the subsequent development of dementia, is reflected in α/θ in the right posterior regions. The right occipital α/θ may represent a useful qEEG marker for evaluating the presence of early signs of cognitive decline in PD and the subsequent risk of dementia.

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