Restoring motor function using optogenetics and neural engraftment: Tissue, cell & pathway engineering (2016)

J Barney Bryson; Carolina Barcellos Machado; Ivo Lieberam; Linda Greensmith

doi:10.1016/j.copbio.2016.02.016

Restoring motor function using optogenetics and neural engraftment: Tissue, cell & pathway engineering (2016)

J Barney Bryson, Carolina Barcellos Machado, Ivo Lieberam, Linda Greensmith

Developmental Neurobiology

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Controlling muscle function is essential for human behaviour and survival, thus, impairment of motor function and muscle paralysis can severely impact quality of life and may be immediately life-threatening, as occurs in many cases of traumatic spinal cord injury (SCI) and in patients with amyotrophic lateral sclerosis (ALS). Repairing damaged spinal motor circuits, in either SCI or ALS, currently remains an elusive goal. Therefore alternative strategies are needed to artificially control muscle function and thereby enable essential motor tasks. This review focuses on recent advances towards restoring motor function, with a particular focus on stem cell-derived neuronal engraftment strategies, optogenetic control of motor function and the potential future translational application of these approaches.

Original language	English
Pages (from-to)	75-81
Number of pages	7
Journal	Current Opinion in Biotechnology
Volume	40
Early online date	24 Mar 2016
DOIs	https://doi.org/10.1016/j.copbio.2016.02.016
Publication status	Published - Aug 2016

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title = "Restoring motor function using optogenetics and neural engraftment: Tissue, cell & pathway engineering (2016)",

abstract = "Controlling muscle function is essential for human behaviour and survival, thus, impairment of motor function and muscle paralysis can severely impact quality of life and may be immediately life-threatening, as occurs in many cases of traumatic spinal cord injury (SCI) and in patients with amyotrophic lateral sclerosis (ALS). Repairing damaged spinal motor circuits, in either SCI or ALS, currently remains an elusive goal. Therefore alternative strategies are needed to artificially control muscle function and thereby enable essential motor tasks. This review focuses on recent advances towards restoring motor function, with a particular focus on stem cell-derived neuronal engraftment strategies, optogenetic control of motor function and the potential future translational application of these approaches.",

author = "Bryson, {J Barney} and Machado, {Carolina Barcellos} and Ivo Lieberam and Linda Greensmith",

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AU - Machado, Carolina Barcellos

AU - Lieberam, Ivo

AU - Greensmith, Linda

PY - 2016/8

Y1 - 2016/8

N2 - Controlling muscle function is essential for human behaviour and survival, thus, impairment of motor function and muscle paralysis can severely impact quality of life and may be immediately life-threatening, as occurs in many cases of traumatic spinal cord injury (SCI) and in patients with amyotrophic lateral sclerosis (ALS). Repairing damaged spinal motor circuits, in either SCI or ALS, currently remains an elusive goal. Therefore alternative strategies are needed to artificially control muscle function and thereby enable essential motor tasks. This review focuses on recent advances towards restoring motor function, with a particular focus on stem cell-derived neuronal engraftment strategies, optogenetic control of motor function and the potential future translational application of these approaches.

AB - Controlling muscle function is essential for human behaviour and survival, thus, impairment of motor function and muscle paralysis can severely impact quality of life and may be immediately life-threatening, as occurs in many cases of traumatic spinal cord injury (SCI) and in patients with amyotrophic lateral sclerosis (ALS). Repairing damaged spinal motor circuits, in either SCI or ALS, currently remains an elusive goal. Therefore alternative strategies are needed to artificially control muscle function and thereby enable essential motor tasks. This review focuses on recent advances towards restoring motor function, with a particular focus on stem cell-derived neuronal engraftment strategies, optogenetic control of motor function and the potential future translational application of these approaches.

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JO - Current Opinion in Biotechnology

JF - Current Opinion in Biotechnology

ER -

Restoring motor function using optogenetics and neural engraftment: Tissue, cell & pathway engineering (2016)

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