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Restoring motor function using optogenetics and neural engraftment: Tissue, cell & pathway engineering (2016)

Research output: Contribution to journalArticle

J Barney Bryson, Carolina Barcellos Machado, Ivo Lieberam, Linda Greensmith

Original languageEnglish
Pages (from-to)75-81
Number of pages7
JournalCurrent Opinion in Biotechnology
Early online date24 Mar 2016
Publication statusPublished - Aug 2016

King's Authors


Controlling muscle function is essential for human behaviour and survival, thus, impairment of motor function and muscle paralysis can severely impact quality of life and may be immediately life-threatening, as occurs in many cases of traumatic spinal cord injury (SCI) and in patients with amyotrophic lateral sclerosis (ALS). Repairing damaged spinal motor circuits, in either SCI or ALS, currently remains an elusive goal. Therefore alternative strategies are needed to artificially control muscle function and thereby enable essential motor tasks. This review focuses on recent advances towards restoring motor function, with a particular focus on stem cell-derived neuronal engraftment strategies, optogenetic control of motor function and the potential future translational application of these approaches.

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