Restriction of retroviral replication by APOBEC3G/F and TRIM5 alpha

Hendrik Huthoff; Greg J. Towers

doi:10.1016/j.tim.2008.08.013

Restriction of retroviral replication by APOBEC3G/F and TRIM5 alpha

Hendrik Huthoff, Greg J. Towers

Infectious Diseases

Research output: Contribution to journal › Literature review › peer-review

79 Citations (Scopus)

Abstract

Pathogenic viral infections have exerted selection pressure on their hosts to evolve cellular antiviral inhibitors referred to as restriction factors. Examples of such molecules are APOBEC3G, APOBEC3F and TRIM5 alpha. APOBEC3G and APOBEC3F are cytidine deaminases that are able to strongly inhibit retroviral replication by at least two mechanisms. They are counteracted by the lentiviral Vif protein. TRIM5a binds to sensitive, incoming retroviruses via its C-terminal PRY/SPRY domain and rapidly recruits them to the proteasome before significant viral DNA synthesis can occur. Both of these proteins robustly block retroviral replication in a species-specific way. It remains an open but important question as to whether innate restriction factors such as these can be harnessed to inhibit HIV-1 replication in humans.

Original language	English
Pages (from-to)	612 - 619
Number of pages	8
Journal	Trends in Microbiology
Volume	16
Issue number	12
DOIs	https://doi.org/10.1016/j.tim.2008.08.013
Publication status	Published - Dec 2008

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title = "Restriction of retroviral replication by APOBEC3G/F and TRIM5 alpha",

abstract = "Pathogenic viral infections have exerted selection pressure on their hosts to evolve cellular antiviral inhibitors referred to as restriction factors. Examples of such molecules are APOBEC3G, APOBEC3F and TRIM5 alpha. APOBEC3G and APOBEC3F are cytidine deaminases that are able to strongly inhibit retroviral replication by at least two mechanisms. They are counteracted by the lentiviral Vif protein. TRIM5a binds to sensitive, incoming retroviruses via its C-terminal PRY/SPRY domain and rapidly recruits them to the proteasome before significant viral DNA synthesis can occur. Both of these proteins robustly block retroviral replication in a species-specific way. It remains an open but important question as to whether innate restriction factors such as these can be harnessed to inhibit HIV-1 replication in humans.",

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T1 - Restriction of retroviral replication by APOBEC3G/F and TRIM5 alpha

AU - Huthoff, Hendrik

AU - Towers, Greg J.

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N2 - Pathogenic viral infections have exerted selection pressure on their hosts to evolve cellular antiviral inhibitors referred to as restriction factors. Examples of such molecules are APOBEC3G, APOBEC3F and TRIM5 alpha. APOBEC3G and APOBEC3F are cytidine deaminases that are able to strongly inhibit retroviral replication by at least two mechanisms. They are counteracted by the lentiviral Vif protein. TRIM5a binds to sensitive, incoming retroviruses via its C-terminal PRY/SPRY domain and rapidly recruits them to the proteasome before significant viral DNA synthesis can occur. Both of these proteins robustly block retroviral replication in a species-specific way. It remains an open but important question as to whether innate restriction factors such as these can be harnessed to inhibit HIV-1 replication in humans.

AB - Pathogenic viral infections have exerted selection pressure on their hosts to evolve cellular antiviral inhibitors referred to as restriction factors. Examples of such molecules are APOBEC3G, APOBEC3F and TRIM5 alpha. APOBEC3G and APOBEC3F are cytidine deaminases that are able to strongly inhibit retroviral replication by at least two mechanisms. They are counteracted by the lentiviral Vif protein. TRIM5a binds to sensitive, incoming retroviruses via its C-terminal PRY/SPRY domain and rapidly recruits them to the proteasome before significant viral DNA synthesis can occur. Both of these proteins robustly block retroviral replication in a species-specific way. It remains an open but important question as to whether innate restriction factors such as these can be harnessed to inhibit HIV-1 replication in humans.

U2 - 10.1016/j.tim.2008.08.013

DO - 10.1016/j.tim.2008.08.013

M3 - Literature review

VL - 16

SP - 612

EP - 619

JO - Trends in Microbiology

JF - Trends in Microbiology

IS - 12

ER -

Restriction of retroviral replication by APOBEC3G/F and TRIM5 alpha

Abstract

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