Retinal ganglion cell dendritic development and its control: Filling the gaps

R J Wingate; Richard Wingate

doi:10.1007/BF02740650

Retinal ganglion cell dendritic development and its control: Filling the gaps

R J Wingate, Richard Wingate

Developmental Neurobiology

GSTT Guy's and St Thomas' NHS Foundation Trust

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

The way in which central neurons acquire their complex and precise dendrite arbors is of considerable developmental interest. Using retinal ganglion cells (RGCs) as a model, the mechanisms that pattern dendritic development are beginning to emerge. As in other systems, final dendrite phenotype is achieved by a mixture of intrinsic and extrinsic determinants. The extrinsic determinants of RGC dendrite shape reflect the anatomical constraints of producing a paracrystalline mosaic of arbors that laminates the inner plexiform layer of the retina. In this article, the key features of RGC dendrite development are reviewed. The emerging molecular mechanisms behind dendritic laminar segregation and "dendritic competition" are described. The role of afferent extrinsic influences are contrasted with those of retrograde, activity-dependent target influences that may regulate the final maturational phase of dendrite remodeling.

Original language	English
Pages (from-to)	133-144
Number of pages	12
Journal	Molecular Neurobiology
Volume	12
Issue number	2
DOIs	https://doi.org/10.1007/BF02740650
Publication status	Published - Apr 1996

Keywords

Animals
Axonal Transport
Dendrites
Models, Neurological
Retina
Retinal Ganglion Cells

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10.1007/BF02740650

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abstract = "The way in which central neurons acquire their complex and precise dendrite arbors is of considerable developmental interest. Using retinal ganglion cells (RGCs) as a model, the mechanisms that pattern dendritic development are beginning to emerge. As in other systems, final dendrite phenotype is achieved by a mixture of intrinsic and extrinsic determinants. The extrinsic determinants of RGC dendrite shape reflect the anatomical constraints of producing a paracrystalline mosaic of arbors that laminates the inner plexiform layer of the retina. In this article, the key features of RGC dendrite development are reviewed. The emerging molecular mechanisms behind dendritic laminar segregation and {"}dendritic competition{"} are described. The role of afferent extrinsic influences are contrasted with those of retrograde, activity-dependent target influences that may regulate the final maturational phase of dendrite remodeling.",

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AU - Wingate, Richard

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AB - The way in which central neurons acquire their complex and precise dendrite arbors is of considerable developmental interest. Using retinal ganglion cells (RGCs) as a model, the mechanisms that pattern dendritic development are beginning to emerge. As in other systems, final dendrite phenotype is achieved by a mixture of intrinsic and extrinsic determinants. The extrinsic determinants of RGC dendrite shape reflect the anatomical constraints of producing a paracrystalline mosaic of arbors that laminates the inner plexiform layer of the retina. In this article, the key features of RGC dendrite development are reviewed. The emerging molecular mechanisms behind dendritic laminar segregation and "dendritic competition" are described. The role of afferent extrinsic influences are contrasted with those of retrograde, activity-dependent target influences that may regulate the final maturational phase of dendrite remodeling.

KW - Animals

KW - Axonal Transport

KW - Dendrites

KW - Models, Neurological

KW - Retina

KW - Retinal Ganglion Cells

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DO - 10.1007/BF02740650

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VL - 12

SP - 133

EP - 144

JO - Molecular Neurobiology

JF - Molecular Neurobiology

IS - 2

ER -

Retinal ganglion cell dendritic development and its control: Filling the gaps

Abstract

Keywords

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