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Retinal microvascular features and cognitive change in the Lothian-Birth Cohort 1936

Research output: Contribution to journalArticlepeer-review

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Retinal microvascular features and cognitive change in the Lothian-Birth Cohort 1936. / McGrory, Sarah; Ballerini, Lucia; Okely, Judith A.; Ritchie, Stuart J.; Doubal, Fergus N.; Doney, Alex S.F.; Dhillon, Baljean; Starr, John M.; MacGillivray, Thomas J.; Trucco, Emanuele; Wardlaw, Joanna M.; Deary, Ian J.

In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, Vol. 11, 01.12.2019, p. 500-509.

Research output: Contribution to journalArticlepeer-review

Harvard

McGrory, S, Ballerini, L, Okely, JA, Ritchie, SJ, Doubal, FN, Doney, ASF, Dhillon, B, Starr, JM, MacGillivray, TJ, Trucco, E, Wardlaw, JM & Deary, IJ 2019, 'Retinal microvascular features and cognitive change in the Lothian-Birth Cohort 1936', Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 11, pp. 500-509. https://doi.org/10.1016/j.dadm.2019.04.012

APA

McGrory, S., Ballerini, L., Okely, J. A., Ritchie, S. J., Doubal, F. N., Doney, A. S. F., Dhillon, B., Starr, J. M., MacGillivray, T. J., Trucco, E., Wardlaw, J. M., & Deary, I. J. (2019). Retinal microvascular features and cognitive change in the Lothian-Birth Cohort 1936. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 11, 500-509. https://doi.org/10.1016/j.dadm.2019.04.012

Vancouver

McGrory S, Ballerini L, Okely JA, Ritchie SJ, Doubal FN, Doney ASF et al. Retinal microvascular features and cognitive change in the Lothian-Birth Cohort 1936. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 2019 Dec 1;11:500-509. https://doi.org/10.1016/j.dadm.2019.04.012

Author

McGrory, Sarah ; Ballerini, Lucia ; Okely, Judith A. ; Ritchie, Stuart J. ; Doubal, Fergus N. ; Doney, Alex S.F. ; Dhillon, Baljean ; Starr, John M. ; MacGillivray, Thomas J. ; Trucco, Emanuele ; Wardlaw, Joanna M. ; Deary, Ian J. / Retinal microvascular features and cognitive change in the Lothian-Birth Cohort 1936. In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 2019 ; Vol. 11. pp. 500-509.

Bibtex Download

@article{950f4df9cc9b43059284247b3fc9a0d5,
title = "Retinal microvascular features and cognitive change in the Lothian-Birth Cohort 1936",
abstract = "Introduction: We test whether measures of the retinal vasculature are associated with cognitive functioning and cognitive change. Methods: Retinal images from a narrow-age cohort were analyzed using Vessel Assessment and Measurement Platform for Images of the Retina, producing a comprehensive range of quantitative measurements of the retinal vasculature, at mean age 72.5 years (SD = 0.7). Cognitive ability and change were measured using a battery of multiple measures of memory, visuospatial, processing speed, and crystallized cognitive abilities at mean ages 73, 76, and 79 years. We applied multivariate growth curve models to test the association between retinal vascular measurements with cognitive abilities and their changes. Results: Almost all associations were nonsignificant. In our most parsimonious model, venular asymmetry factor was associated with speed at age 73. Discussion: Our null findings suggest that the quantitative retinal parameters applied in this study are not significantly associated with cognitive functioning or cognitive change.",
keywords = "Cognitive change, Longitudinal study, Retinal imaging",
author = "Sarah McGrory and Lucia Ballerini and Okely, {Judith A.} and Ritchie, {Stuart J.} and Doubal, {Fergus N.} and Doney, {Alex S.F.} and Baljean Dhillon and Starr, {John M.} and MacGillivray, {Thomas J.} and Emanuele Trucco and Wardlaw, {Joanna M.} and Deary, {Ian J.}",
year = "2019",
month = dec,
day = "1",
doi = "10.1016/j.dadm.2019.04.012",
language = "English",
volume = "11",
pages = "500--509",
journal = "Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring",
issn = "2352-8729",
publisher = "Elsevier BV",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Retinal microvascular features and cognitive change in the Lothian-Birth Cohort 1936

AU - McGrory, Sarah

AU - Ballerini, Lucia

AU - Okely, Judith A.

AU - Ritchie, Stuart J.

AU - Doubal, Fergus N.

AU - Doney, Alex S.F.

AU - Dhillon, Baljean

AU - Starr, John M.

AU - MacGillivray, Thomas J.

AU - Trucco, Emanuele

AU - Wardlaw, Joanna M.

AU - Deary, Ian J.

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Introduction: We test whether measures of the retinal vasculature are associated with cognitive functioning and cognitive change. Methods: Retinal images from a narrow-age cohort were analyzed using Vessel Assessment and Measurement Platform for Images of the Retina, producing a comprehensive range of quantitative measurements of the retinal vasculature, at mean age 72.5 years (SD = 0.7). Cognitive ability and change were measured using a battery of multiple measures of memory, visuospatial, processing speed, and crystallized cognitive abilities at mean ages 73, 76, and 79 years. We applied multivariate growth curve models to test the association between retinal vascular measurements with cognitive abilities and their changes. Results: Almost all associations were nonsignificant. In our most parsimonious model, venular asymmetry factor was associated with speed at age 73. Discussion: Our null findings suggest that the quantitative retinal parameters applied in this study are not significantly associated with cognitive functioning or cognitive change.

AB - Introduction: We test whether measures of the retinal vasculature are associated with cognitive functioning and cognitive change. Methods: Retinal images from a narrow-age cohort were analyzed using Vessel Assessment and Measurement Platform for Images of the Retina, producing a comprehensive range of quantitative measurements of the retinal vasculature, at mean age 72.5 years (SD = 0.7). Cognitive ability and change were measured using a battery of multiple measures of memory, visuospatial, processing speed, and crystallized cognitive abilities at mean ages 73, 76, and 79 years. We applied multivariate growth curve models to test the association between retinal vascular measurements with cognitive abilities and their changes. Results: Almost all associations were nonsignificant. In our most parsimonious model, venular asymmetry factor was associated with speed at age 73. Discussion: Our null findings suggest that the quantitative retinal parameters applied in this study are not significantly associated with cognitive functioning or cognitive change.

KW - Cognitive change

KW - Longitudinal study

KW - Retinal imaging

UR - http://www.scopus.com/inward/record.url?scp=85068511440&partnerID=8YFLogxK

U2 - 10.1016/j.dadm.2019.04.012

DO - 10.1016/j.dadm.2019.04.012

M3 - Article

AN - SCOPUS:85068511440

VL - 11

SP - 500

EP - 509

JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

SN - 2352-8729

ER -

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