Retrospectively assessed childhood trauma experiences are associated with illness severity in mental disorders adjusted for symptom state

Monica Aas; Torill Ueland; Trine V Lagerberg; Ingrid Melle; Sofie R Aminoff; Margrethe C Hoegh; Synve Hoffart Lunding; Jannicke F Laskemoen; Nils Eiel Steen; Ole A Andreassen

doi:10.1016/j.psychres.2022.115045

Retrospectively assessed childhood trauma experiences are associated with illness severity in mental disorders adjusted for symptom state

Monica Aas, Torill Ueland, Trine V Lagerberg, Ingrid Melle, Sofie R Aminoff, Margrethe C Hoegh, Synve Hoffart Lunding, Jannicke F Laskemoen, Nils Eiel Steen, Ole A Andreassen

Social Genetic & Developmental Psychiatry

1] NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway [2] Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway [3] Centre for Molecular Medicine Norway, Nordic EMBL Partnership, University of Oslo and Oslo University Hospital, Oslo, Norway.
Division of Mental Health and Addiction

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Converging evidence suggests that childhood trauma is a causal factor in schizophrenia (SZ) and in bipolar disorders (BD). Here, we investigated whether retrospective reports are associated with severity of illness, independent of current symptom state in a large sample of participants with SZ or BD. We included 1260 individuals (SZ [n = 461], BD [n = 352]), and healthy controls; HC [n = 447]) recruited from the same catchment area. A history of childhood trauma was obtained with the Childhood Trauma Questionnaire (CTQ). Diagnosis and episodes were obtained with the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I). Clinical symptoms (state) were assessed with the Positive and Negative Syndrome scale (PANSS), the Calgary Depression Scale (CDSS). Trait related illness characteristics were assessed with age at illness onset, number of episodes, and lifetime suicide attempts. Patients who reported multiple types of childhood trauma experiences had significantly more severe illness course including an earlier illness onset, more mood episodes, and increased risk of at least one suicide attempt, also after adjusting for current symptom state. Retrospective assessed childhood trauma experiences are associated with illness severity in mental disorders adjusted for symptom state. Our results strengthen the role of childhood trauma in development of psychopathology.

Original language	English
Article number	115045
Pages (from-to)	115045
Journal	Psychiatry Research
Volume	320
DOIs	https://doi.org/10.1016/j.psychres.2022.115045
Publication status	Published - 1 Feb 2023

Keywords

Humans
Retrospective Studies
Adverse Childhood Experiences
Bipolar Disorder/diagnosis
Schizophrenia/epidemiology
Patient Acuity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.psychres.2022.115045

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Aas, M., Ueland, T., Lagerberg, T. V., Melle, I., Aminoff, S. R., Hoegh, M. C., Lunding, S. H., Laskemoen, J. F., Steen, N. E., & Andreassen, O. A. (2023). Retrospectively assessed childhood trauma experiences are associated with illness severity in mental disorders adjusted for symptom state. Psychiatry Research, 320, 115045. Article 115045. https://doi.org/10.1016/j.psychres.2022.115045

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title = "Retrospectively assessed childhood trauma experiences are associated with illness severity in mental disorders adjusted for symptom state",

abstract = "Converging evidence suggests that childhood trauma is a causal factor in schizophrenia (SZ) and in bipolar disorders (BD). Here, we investigated whether retrospective reports are associated with severity of illness, independent of current symptom state in a large sample of participants with SZ or BD. We included 1260 individuals (SZ [n = 461], BD [n = 352]), and healthy controls; HC [n = 447]) recruited from the same catchment area. A history of childhood trauma was obtained with the Childhood Trauma Questionnaire (CTQ). Diagnosis and episodes were obtained with the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I). Clinical symptoms (state) were assessed with the Positive and Negative Syndrome scale (PANSS), the Calgary Depression Scale (CDSS). Trait related illness characteristics were assessed with age at illness onset, number of episodes, and lifetime suicide attempts. Patients who reported multiple types of childhood trauma experiences had significantly more severe illness course including an earlier illness onset, more mood episodes, and increased risk of at least one suicide attempt, also after adjusting for current symptom state. Retrospective assessed childhood trauma experiences are associated with illness severity in mental disorders adjusted for symptom state. Our results strengthen the role of childhood trauma in development of psychopathology.",

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author = "Monica Aas and Torill Ueland and Lagerberg, {Trine V} and Ingrid Melle and Aminoff, {Sofie R} and Hoegh, {Margrethe C} and Lunding, {Synve Hoffart} and Laskemoen, {Jannicke F} and Steen, {Nils Eiel} and Andreassen, {Ole A}",

note = "Funding Information: This study was funded by grants from the South-Eastern Norway Health Authority (# 2017060 ), the Research Council of Norway (# 223273 ), the KG Jebsen Stiftelsen, the NARSAD Young Investigator Award (# 22388 ) and the MRC Career Development Award to Monica Aas (# MR/WO27720/1) . Funding Information: This study was funded by grants from the South-Eastern Norway Health Authority (#2017060), the Research Council of Norway (#223273), the KG Jebsen Stiftelsen, the NARSAD Young Investigator Award (#22388) and the MRC Career Development Award to Monica Aas (#MR/WO27720/1). Publisher Copyright: {\textcopyright} 2022",

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AU - Aas, Monica

AU - Ueland, Torill

AU - Lagerberg, Trine V

AU - Melle, Ingrid

AU - Aminoff, Sofie R

AU - Hoegh, Margrethe C

AU - Lunding, Synve Hoffart

AU - Laskemoen, Jannicke F

AU - Steen, Nils Eiel

AU - Andreassen, Ole A

N1 - Funding Information: This study was funded by grants from the South-Eastern Norway Health Authority (# 2017060 ), the Research Council of Norway (# 223273 ), the KG Jebsen Stiftelsen, the NARSAD Young Investigator Award (# 22388 ) and the MRC Career Development Award to Monica Aas (# MR/WO27720/1) . Funding Information: This study was funded by grants from the South-Eastern Norway Health Authority (#2017060), the Research Council of Norway (#223273), the KG Jebsen Stiftelsen, the NARSAD Young Investigator Award (#22388) and the MRC Career Development Award to Monica Aas (#MR/WO27720/1). Publisher Copyright: © 2022

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N2 - Converging evidence suggests that childhood trauma is a causal factor in schizophrenia (SZ) and in bipolar disorders (BD). Here, we investigated whether retrospective reports are associated with severity of illness, independent of current symptom state in a large sample of participants with SZ or BD. We included 1260 individuals (SZ [n = 461], BD [n = 352]), and healthy controls; HC [n = 447]) recruited from the same catchment area. A history of childhood trauma was obtained with the Childhood Trauma Questionnaire (CTQ). Diagnosis and episodes were obtained with the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I). Clinical symptoms (state) were assessed with the Positive and Negative Syndrome scale (PANSS), the Calgary Depression Scale (CDSS). Trait related illness characteristics were assessed with age at illness onset, number of episodes, and lifetime suicide attempts. Patients who reported multiple types of childhood trauma experiences had significantly more severe illness course including an earlier illness onset, more mood episodes, and increased risk of at least one suicide attempt, also after adjusting for current symptom state. Retrospective assessed childhood trauma experiences are associated with illness severity in mental disorders adjusted for symptom state. Our results strengthen the role of childhood trauma in development of psychopathology.

AB - Converging evidence suggests that childhood trauma is a causal factor in schizophrenia (SZ) and in bipolar disorders (BD). Here, we investigated whether retrospective reports are associated with severity of illness, independent of current symptom state in a large sample of participants with SZ or BD. We included 1260 individuals (SZ [n = 461], BD [n = 352]), and healthy controls; HC [n = 447]) recruited from the same catchment area. A history of childhood trauma was obtained with the Childhood Trauma Questionnaire (CTQ). Diagnosis and episodes were obtained with the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I). Clinical symptoms (state) were assessed with the Positive and Negative Syndrome scale (PANSS), the Calgary Depression Scale (CDSS). Trait related illness characteristics were assessed with age at illness onset, number of episodes, and lifetime suicide attempts. Patients who reported multiple types of childhood trauma experiences had significantly more severe illness course including an earlier illness onset, more mood episodes, and increased risk of at least one suicide attempt, also after adjusting for current symptom state. Retrospective assessed childhood trauma experiences are associated with illness severity in mental disorders adjusted for symptom state. Our results strengthen the role of childhood trauma in development of psychopathology.

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KW - Retrospective Studies

KW - Adverse Childhood Experiences

KW - Bipolar Disorder/diagnosis

KW - Schizophrenia/epidemiology

KW - Patient Acuity

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DO - 10.1016/j.psychres.2022.115045

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SN - 0165-1781

VL - 320

SP - 115045

JO - Psychiatry Research

JF - Psychiatry Research

M1 - 115045

ER -

Retrospectively assessed childhood trauma experiences are associated with illness severity in mental disorders adjusted for symptom state

Abstract

Keywords

UN SDGs

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