TY - CHAP
T1 - Revealing differences in anatomical remodelling of the systemic right ventricle
AU - Zacur, Ernesto
AU - Wong, James
AU - Razavi, Reza
AU - Geva, Tal
AU - Greil, Gerald
AU - Lamata, Pablo
PY - 2015/6/21
Y1 - 2015/6/21
N2 - Cardiac remodelling, which refers to the change of the shape and size of the myocardium, is an adaptive response to developmental, disease and surgical processes. Traditional metrics of length, volume, aspect ratio or wall thickness are used in the clinic and in medical research, but have limited capabilities to describe complex structures such as the shape of cardiac ventricles. In this work we present an example of how computational analysis of cardiac anatomy can reveal more detailed description of developmental and remodelling patterns. The clinical problem is the analysis of the impact of two different surgical palliation techniques for hypoplastic left heart syndrome. Construction of a computational atlas and the statistical description of its variability are performed from the short axis stack of 128 subjects. Results unveil, for the first time in the literature, the differences in remodelling of the systemic right ventricle depending on the surgical palliation technique.
AB - Cardiac remodelling, which refers to the change of the shape and size of the myocardium, is an adaptive response to developmental, disease and surgical processes. Traditional metrics of length, volume, aspect ratio or wall thickness are used in the clinic and in medical research, but have limited capabilities to describe complex structures such as the shape of cardiac ventricles. In this work we present an example of how computational analysis of cardiac anatomy can reveal more detailed description of developmental and remodelling patterns. The clinical problem is the analysis of the impact of two different surgical palliation techniques for hypoplastic left heart syndrome. Construction of a computational atlas and the statistical description of its variability are performed from the short axis stack of 128 subjects. Results unveil, for the first time in the literature, the differences in remodelling of the systemic right ventricle depending on the surgical palliation technique.
KW - Computational anatomy
KW - Discriminative analysis
KW - Statistical shape analysis
KW - Systemic right ventricle
UR - http://www.scopus.com/inward/record.url?scp=84949981626&partnerID=8YFLogxK
U2 - 10.1007/978-3-319-20309-6_12
DO - 10.1007/978-3-319-20309-6_12
M3 - Conference paper
AN - SCOPUS:84949981626
SN - 9783319203089
SN - 9783319203089
VL - 9126
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 99
EP - 107
BT - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
PB - Springer‐Verlag Berlin Heidelberg
T2 - 8th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2015
Y2 - 25 June 2015 through 27 June 2015
ER -