Revealing the inner workings of organoids

Cristina Dias, François Guillemot

Research output: Contribution to journalReview article

8 Citations (Scopus)


The mechanisms by which human stem cells self‐organise into brain‐like tissues in 3D organoid culture are poorly understood. In this issue of The EMBO Journal, Renner and Lancaster et al demonstrate that in the absence of external stimuli, human cerebral organoids develop large forebrain structures that display specific landmarks of spatial and temporal patterning, including signalling centres producing known morphogens. The generation of cerebral organoids is therefore likely to reflect normal brain development.
Original languageEnglish
Pages (from-to)1299-1301
JournalThe EMBO journal
Early online date24 Apr 2017
Publication statusPublished - 15 May 2017


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