Revealing the inner workings of organoids

TY - JOUR

T1 - Revealing the inner workings of organoids

AU - Dias, Cristina

AU - Guillemot, François

PY - 2017/5/15

Y1 - 2017/5/15

N2 - The mechanisms by which human stem cells self‐organise into brain‐like tissues in 3D organoid culture are poorly understood. In this issue of The EMBO Journal, Renner and Lancaster et al demonstrate that in the absence of external stimuli, human cerebral organoids develop large forebrain structures that display specific landmarks of spatial and temporal patterning, including signalling centres producing known morphogens. The generation of cerebral organoids is therefore likely to reflect normal brain development.

AB - The mechanisms by which human stem cells self‐organise into brain‐like tissues in 3D organoid culture are poorly understood. In this issue of The EMBO Journal, Renner and Lancaster et al demonstrate that in the absence of external stimuli, human cerebral organoids develop large forebrain structures that display specific landmarks of spatial and temporal patterning, including signalling centres producing known morphogens. The generation of cerebral organoids is therefore likely to reflect normal brain development.

U2 - 10.15252/embj.201796860

DO - 10.15252/embj.201796860

M3 - Review article

SN - 0261-4189

VL - 36

SP - 1299

EP - 1301

JO - The EMBO journal

JF - The EMBO journal

ER -