TY - JOUR
T1 - Revealing the mechanisms behind novel auditory stimuli discrimination
T2 - An evaluation of silent functional MRI using looping star
AU - Damestani, Nikou L
AU - O'Daly, Owen
AU - Solana, Ana Beatriz
AU - Wiesinger, Florian
AU - Lythgoe, David J
AU - Hill, Simon
AU - de Lara Rubio, Alfonso
AU - Makovac, Elena
AU - Williams, Steven C R
AU - Zelaya, Fernando
N1 - Funding Information:
This study was funded by the NIHR Maudsley Biomedical Research Centre Novel Neuroimaging Approaches Research Call (grant number: IS-BRC-1215-20018). This study represents independent research supported by the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London. Nikou Damestani is in receipt of a PhD studentship funded by the NIHR Maudsley Biomedical Research Centre. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care. The authors also wish to thank the Wellcome Trust for their ongoing support of our neuroimaging research. We would also like to thank Professor Gareth J Barker, Dr Emil Ljungberg and Dr Tobias C Wood for their assistance during this project. We also thank Dr Jos? Alc?ntara, Dr Marie Gomot and Dr Bernhard M?ller for sharing and building the set of sounds used in the oddball paradigm.
Publisher Copyright:
© 2021 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/6/15
Y1 - 2021/6/15
N2 - Looping Star is a near-silent, multi-echo, 3D functional magnetic resonance imaging (fMRI) technique. It reduces acoustic noise by at least 25dBA, with respect to gradient-recalled echo echo-planar imaging (GRE-EPI)-based fMRI. Looping Star has successfully demonstrated sensitivity to the cerebral blood-oxygen-level-dependent (BOLD) response during block design paradigms but has not been applied to event-related auditory perception tasks. Demonstrating Looping Star's sensitivity to such tasks could (a) provide new insights into auditory processing studies, (b) minimise the need for invasive ear protection, and (c) facilitate the translation of numerous fMRI studies to investigations in sound-averse patients. We aimed to demonstrate, for the first time, that multi-echo Looping Star has sufficient sensitivity to the BOLD response, compared to that of GRE-EPI, during a well-established event-related auditory discrimination paradigm: the "oddball" task. We also present the first quantitative evaluation of Looping Star's test-retest reliability using the intra-class correlation coefficient. Twelve participants were scanned using single-echo GRE-EPI and multi-echo Looping Star fMRI in two sessions. Random-effects analyses were performed, evaluating the overall response to tones and differential tone recognition, and intermodality analyses were computed. We found that multi-echo Looping Star exhibited consistent sensitivity to auditory stimulation relative to GRE-EPI. However, Looping Star demonstrated lower test-retest reliability in comparison with GRE-EPI. This could reflect differences in functional sensitivity between the techniques, though further study is necessary with additional cognitive paradigms as varying cognitive strategies between sessions may arise from elimination of acoustic scanner noise.
AB - Looping Star is a near-silent, multi-echo, 3D functional magnetic resonance imaging (fMRI) technique. It reduces acoustic noise by at least 25dBA, with respect to gradient-recalled echo echo-planar imaging (GRE-EPI)-based fMRI. Looping Star has successfully demonstrated sensitivity to the cerebral blood-oxygen-level-dependent (BOLD) response during block design paradigms but has not been applied to event-related auditory perception tasks. Demonstrating Looping Star's sensitivity to such tasks could (a) provide new insights into auditory processing studies, (b) minimise the need for invasive ear protection, and (c) facilitate the translation of numerous fMRI studies to investigations in sound-averse patients. We aimed to demonstrate, for the first time, that multi-echo Looping Star has sufficient sensitivity to the BOLD response, compared to that of GRE-EPI, during a well-established event-related auditory discrimination paradigm: the "oddball" task. We also present the first quantitative evaluation of Looping Star's test-retest reliability using the intra-class correlation coefficient. Twelve participants were scanned using single-echo GRE-EPI and multi-echo Looping Star fMRI in two sessions. Random-effects analyses were performed, evaluating the overall response to tones and differential tone recognition, and intermodality analyses were computed. We found that multi-echo Looping Star exhibited consistent sensitivity to auditory stimulation relative to GRE-EPI. However, Looping Star demonstrated lower test-retest reliability in comparison with GRE-EPI. This could reflect differences in functional sensitivity between the techniques, though further study is necessary with additional cognitive paradigms as varying cognitive strategies between sessions may arise from elimination of acoustic scanner noise.
UR - http://www.scopus.com/inward/record.url?scp=85102639806&partnerID=8YFLogxK
U2 - 10.1002/hbm.25407
DO - 10.1002/hbm.25407
M3 - Article
C2 - 33729637
SN - 1065-9471
VL - 42
SP - 2833
EP - 2850
JO - Human Brain Mapping
JF - Human Brain Mapping
IS - 9
ER -