Revisiting the flight of icarus: Making human organs from PSCs with large animal chimeras

Tamir Rashid, Toshihiro Kobayashi, Hiromitsu Nakauchi*

*Corresponding author for this work

Research output: Contribution to journalComment/debatepeer-review

91 Citations (Scopus)

Abstract

While cell therapies hold great potential for treating many conditions, their utility for treating patients that require whole organ replacement is unclear. To address this challenge, we propose using genetically engineered "organ niches" in large animals to generate human organs from pluripotent stem cells and discuss the hurdles facing such strategies.

Original languageEnglish
Pages (from-to)406-409
Number of pages4
JournalCell Stem Cell
Volume15
Issue number4
DOIs
Publication statusPublished - 1 Jan 2014

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