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Revisiting the role of B cells in skin immune surveillance

Research output: Contribution to journalReview articlepeer-review

Original languageEnglish
Pages (from-to)102-111
Number of pages10
JournalTRENDS IN IMMUNOLOGY
Volume36
Issue number2
Early online date21 Jan 2015
DOIs
E-pub ahead of print21 Jan 2015
PublishedFeb 2015

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King's Authors

Abstract

Whereas our understanding of the skin immune system has increased exponentially in recent years, the role of B cells in cutaneous immunity remains poorly defined. Recent studies have revealed the presence of B cells within lymphocytic infiltrates in chronic inflammatory skin diseases and cutaneous malignancies including melanoma, and have examined their functional significance in these settings. We review these findings and discuss them in the context of the current understanding of the role of B cells in normal skin physiology, as well as in both animal and human models of skin pathology. We integrate these findings into a model of cutaneous immunity wherein crosstalk between B cells and other skin-resident immune cells plays a central role in skin immune homeostasis.

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