King's College London

Research portal

Revisiting the role of B cells in skin immune surveillance

Research output: Contribution to journalReview articlepeer-review

Original languageEnglish
Pages (from-to)102-111
Number of pages10
Issue number2
Early online date21 Jan 2015
E-pub ahead of print21 Jan 2015
PublishedFeb 2015


King's Authors


Whereas our understanding of the skin immune system has increased exponentially in recent years, the role of B cells in cutaneous immunity remains poorly defined. Recent studies have revealed the presence of B cells within lymphocytic infiltrates in chronic inflammatory skin diseases and cutaneous malignancies including melanoma, and have examined their functional significance in these settings. We review these findings and discuss them in the context of the current understanding of the role of B cells in normal skin physiology, as well as in both animal and human models of skin pathology. We integrate these findings into a model of cutaneous immunity wherein crosstalk between B cells and other skin-resident immune cells plays a central role in skin immune homeostasis.

Download statistics

No data available

View graph of relations

© 2020 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454