Rhinovirus infections and immunisation induce cross-serotype reactive antibodies to VP1

Gary R McLean, Ross P Walton, Shweta Shetty, Tamlyn J Peel, Nasren Paktiawal, Tatiana Kebadze, Leila Gogsadze, Katarzyna Niespodziana, Rudolf Valenta, Nathan W Bartlett, Sebastian L Johnston

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)


Rhinoviruses (RVs) are ubiquitous human respiratory viruses, the major cause of common colds, acute exacerbations of asthma and other respiratory diseases. The development of antibodies to RV following primary infection is poorly understood and there is currently no RV vaccine available. We therefore used mouse models of intranasal RV infection and immunisation to determine the induction, magnitude and specificity of antibody responses. Strong cross-serotype RV-specific IgG responses in serum and bronchoalveolar lavage were induced towards the RV capsid protein VP1. IgA responses were weaker, requiring two infections to generate detectable RV-specific binding. Similarly two or more RV infections were necessary to induce neutralising antibodies. Immunisation strategies boosted homotypic as well as inducing cross-serotype neutralising IgG responses. We conclude that VP1 based antigens combined with adjuvants may permit successful antibody-mediated vaccine design and development.
Original languageEnglish
Pages (from-to)193-201
Number of pages9
JournalAntiviral Research
Issue number3
Publication statusPublished - Sept 2012


  • Animals
  • Antibodies, Neutralizing
  • Antibodies, Viral
  • Bronchoalveolar Lavage Fluid
  • Cross Reactions
  • Disease Models, Animal
  • Female
  • Immunoglobulin A
  • Immunoglobulin G
  • Mice
  • Mice, Inbred BALB C
  • Picornaviridae Infections
  • Rhinovirus
  • Viral Proteins
  • Viral Vaccines


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