Rho-GTPase signaling drives melanoma cell plasticity

Vicky Sanz Moreno, Christopher J. Marshall

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)


To investigate mechanisms that underlie different modes of tumor cell movement we have studied how regulation of the activity of the Rho family GTPases determines the mode of tumor cell movement. Guanine nucleotide exchange factors (GEFs) and GTPase accelerating proteins (GAPs) are key regulators of the activity of small GTPases with GEFs promoting activation to the GTP bound state and GAPs promoting inactivation by stimulating GTP hydrolysis. We identified two important signaling pathways regulating amoeboid and mesenchymal types of motility in melanoma. Here, we discuss our findings in the context of how specificity of Rho signaling is achieved by GEFs and GAPs.

Original languageEnglish
Pages (from-to)1484-1487
Number of pages4
Issue number10
Publication statusPublished - 15 May 2009


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