Rho-GTPase signaling drives melanoma cell plasticity

TY - JOUR

T1 - Rho-GTPase signaling drives melanoma cell plasticity

AU - Sanz Moreno, Vicky

AU - Marshall, Christopher J.

PY - 2009/5/15

Y1 - 2009/5/15

N2 - To investigate mechanisms that underlie different modes of tumor cell movement we have studied how regulation of the activity of the Rho family GTPases determines the mode of tumor cell movement. Guanine nucleotide exchange factors (GEFs) and GTPase accelerating proteins (GAPs) are key regulators of the activity of small GTPases with GEFs promoting activation to the GTP bound state and GAPs promoting inactivation by stimulating GTP hydrolysis. We identified two important signaling pathways regulating amoeboid and mesenchymal types of motility in melanoma. Here, we discuss our findings in the context of how specificity of Rho signaling is achieved by GEFs and GAPs.

AB - To investigate mechanisms that underlie different modes of tumor cell movement we have studied how regulation of the activity of the Rho family GTPases determines the mode of tumor cell movement. Guanine nucleotide exchange factors (GEFs) and GTPase accelerating proteins (GAPs) are key regulators of the activity of small GTPases with GEFs promoting activation to the GTP bound state and GAPs promoting inactivation by stimulating GTP hydrolysis. We identified two important signaling pathways regulating amoeboid and mesenchymal types of motility in melanoma. Here, we discuss our findings in the context of how specificity of Rho signaling is achieved by GEFs and GAPs.

U2 - 10.4161/cc.8.10.8490

DO - 10.4161/cc.8.10.8490

M3 - Article

VL - 8

SP - 1484

EP - 1487

JO - CELL CYCLE

JF - CELL CYCLE

IS - 10

ER -