Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking

A J Ridley

doi:10.1016/j.tcb.2006.08.006

Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking

A J Ridley

Research output: Contribution to journal › Literature review › peer-review

978 Citations (Scopus)

Abstract

Rho GTPases are well known to regulate actin dynamics. They activate two types of actin nucleators, WASP/WAVE proteins and Diaphanous-related formins (DRFs), which induce different types of actin organization. Their ability to interact with membranes allows them to target actin polymerization to discrete sites on the plasma membrane and to intracellular membrane compartments and thereby induce membrane protrusions or regulate vesicle movement. Most studies have concentrated on just three of the 22 mammalian Rho proteins, RhoA, Rac1 and Cdc42. However, recent research indicates that several other members of the Rho family, including Rif, RholD, TC10 and Wrch1, and also related Rho-of-plants proteins (ROPs) in plants, stimulate actin polymerization and affect plasma membrane protrusion and/or vesicular traffic

Original language	English
Pages (from-to)	522 - 529
Number of pages	8
Journal	TRENDS IN CELL BIOLOGY
Volume	16
Issue number	10
DOIs	https://doi.org/10.1016/j.tcb.2006.08.006
Publication status	Published - Oct 2006

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title = "Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking",

abstract = "Rho GTPases are well known to regulate actin dynamics. They activate two types of actin nucleators, WASP/WAVE proteins and Diaphanous-related formins (DRFs), which induce different types of actin organization. Their ability to interact with membranes allows them to target actin polymerization to discrete sites on the plasma membrane and to intracellular membrane compartments and thereby induce membrane protrusions or regulate vesicle movement. Most studies have concentrated on just three of the 22 mammalian Rho proteins, RhoA, Rac1 and Cdc42. However, recent research indicates that several other members of the Rho family, including Rif, RholD, TC10 and Wrch1, and also related Rho-of-plants proteins (ROPs) in plants, stimulate actin polymerization and affect plasma membrane protrusion and/or vesicular traffic",

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doi = "10.1016/j.tcb.2006.08.006",

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T1 - Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking

AU - Ridley, A J

PY - 2006/10

Y1 - 2006/10

N2 - Rho GTPases are well known to regulate actin dynamics. They activate two types of actin nucleators, WASP/WAVE proteins and Diaphanous-related formins (DRFs), which induce different types of actin organization. Their ability to interact with membranes allows them to target actin polymerization to discrete sites on the plasma membrane and to intracellular membrane compartments and thereby induce membrane protrusions or regulate vesicle movement. Most studies have concentrated on just three of the 22 mammalian Rho proteins, RhoA, Rac1 and Cdc42. However, recent research indicates that several other members of the Rho family, including Rif, RholD, TC10 and Wrch1, and also related Rho-of-plants proteins (ROPs) in plants, stimulate actin polymerization and affect plasma membrane protrusion and/or vesicular traffic

AB - Rho GTPases are well known to regulate actin dynamics. They activate two types of actin nucleators, WASP/WAVE proteins and Diaphanous-related formins (DRFs), which induce different types of actin organization. Their ability to interact with membranes allows them to target actin polymerization to discrete sites on the plasma membrane and to intracellular membrane compartments and thereby induce membrane protrusions or regulate vesicle movement. Most studies have concentrated on just three of the 22 mammalian Rho proteins, RhoA, Rac1 and Cdc42. However, recent research indicates that several other members of the Rho family, including Rif, RholD, TC10 and Wrch1, and also related Rho-of-plants proteins (ROPs) in plants, stimulate actin polymerization and affect plasma membrane protrusion and/or vesicular traffic

U2 - 10.1016/j.tcb.2006.08.006

DO - 10.1016/j.tcb.2006.08.006

M3 - Literature review

VL - 16

SP - 522

EP - 529

JO - TRENDS IN CELL BIOLOGY

JF - TRENDS IN CELL BIOLOGY

IS - 10

ER -

Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking

Abstract

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