Rho GTPases and cell cycle control

P Villalonga, A J Ridley

Research output: Contribution to journalLiterature reviewpeer-review

80 Citations (Scopus)

Abstract

Members of the Rho family of small GTPases are crucial regulators of biological responses in eukaryotic cells, including cytoskeletal dynamics, cell motility and cell cycle progression. In the present review, we summarize our current understanding of the role of Rho proteins in cell cycle control, highlighting the contribution of specific members of the Rho family and their downstream targets to the regulation of key elements from the core cell cycle machinery, mostly involved in the G1/S transition
Original languageEnglish
Pages (from-to)159 - 164
Number of pages6
JournalGrowth Factors
Volume24
Issue number3
DOIs
Publication statusPublished - Sept 2006

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