Rho GTPases modulate malignant transformation of tumor cells

Jose L. Orgazy, Cecilia Herraizy, Vicky Sanz Moreno*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

115 Citations (Scopus)

Abstract

Rho GTPases are involved in the acquisition of all the hallmarks of cancer, which comprise 6 biological capabilities acquired during the development of human tumors. The hallmarks include proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, and activating invasion and metastasis programs, as defined by Hanahan and Weinberg.1 Controlling these hallmarks are genome instability and inflammation. Emerging hallmarks are reprogramming of energy metabolism and evading immune destruction. To give a different view to the readers, we will not be focusing on invasion, metastasis, or cytoskeletal remodeling, but we will review here how Rho GTPases contribute to other hallmarks of cancer with a special emphasis on malignant transformation.

Original languageEnglish
Pages (from-to)1-15
Number of pages15
JournalSmall GTPases
Volume5
Issue number4
DOIs
Publication statusPublished - 31 Oct 2014

Keywords

  • Metabolism inflammation
  • Oncogene
  • Proliferation
  • Rho GTPases
  • Senescence
  • Survival
  • Transformation
  • Tumor progression

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