Rho GTPases modulate malignant transformation of tumor cells

Jose L. Orgazy; Cecilia Herraizy; Vicky Sanz Moreno

doi:10.4161/sgtp.29019

Rho GTPases modulate malignant transformation of tumor cells

Jose L. Orgazy, Cecilia Herraizy, Vicky Sanz Moreno^*

^*Corresponding author for this work

King's College London

Research output: Contribution to journal › Article › peer-review

119 Citations (Scopus)

Abstract

Rho GTPases are involved in the acquisition of all the hallmarks of cancer, which comprise 6 biological capabilities acquired during the development of human tumors. The hallmarks include proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, and activating invasion and metastasis programs, as defined by Hanahan and Weinberg.1 Controlling these hallmarks are genome instability and inflammation. Emerging hallmarks are reprogramming of energy metabolism and evading immune destruction. To give a different view to the readers, we will not be focusing on invasion, metastasis, or cytoskeletal remodeling, but we will review here how Rho GTPases contribute to other hallmarks of cancer with a special emphasis on malignant transformation.

Original language	English
Pages (from-to)	1-15
Number of pages	15
Journal	Small GTPases
Volume	5
Issue number	4
DOIs	https://doi.org/10.4161/sgtp.29019
Publication status	Published - 31 Oct 2014

Keywords

Metabolism inflammation
Oncogene
Proliferation
Rho GTPases
Senescence
Survival
Transformation
Tumor progression

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4161/sgtp.29019

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title = "Rho GTPases modulate malignant transformation of tumor cells",

abstract = "Rho GTPases are involved in the acquisition of all the hallmarks of cancer, which comprise 6 biological capabilities acquired during the development of human tumors. The hallmarks include proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, and activating invasion and metastasis programs, as defined by Hanahan and Weinberg.1 Controlling these hallmarks are genome instability and inflammation. Emerging hallmarks are reprogramming of energy metabolism and evading immune destruction. To give a different view to the readers, we will not be focusing on invasion, metastasis, or cytoskeletal remodeling, but we will review here how Rho GTPases contribute to other hallmarks of cancer with a special emphasis on malignant transformation.",

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T1 - Rho GTPases modulate malignant transformation of tumor cells

AU - Orgazy, Jose L.

AU - Herraizy, Cecilia

AU - Sanz Moreno, Vicky

PY - 2014/10/31

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N2 - Rho GTPases are involved in the acquisition of all the hallmarks of cancer, which comprise 6 biological capabilities acquired during the development of human tumors. The hallmarks include proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, and activating invasion and metastasis programs, as defined by Hanahan and Weinberg.1 Controlling these hallmarks are genome instability and inflammation. Emerging hallmarks are reprogramming of energy metabolism and evading immune destruction. To give a different view to the readers, we will not be focusing on invasion, metastasis, or cytoskeletal remodeling, but we will review here how Rho GTPases contribute to other hallmarks of cancer with a special emphasis on malignant transformation.

AB - Rho GTPases are involved in the acquisition of all the hallmarks of cancer, which comprise 6 biological capabilities acquired during the development of human tumors. The hallmarks include proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, and activating invasion and metastasis programs, as defined by Hanahan and Weinberg.1 Controlling these hallmarks are genome instability and inflammation. Emerging hallmarks are reprogramming of energy metabolism and evading immune destruction. To give a different view to the readers, we will not be focusing on invasion, metastasis, or cytoskeletal remodeling, but we will review here how Rho GTPases contribute to other hallmarks of cancer with a special emphasis on malignant transformation.

KW - Metabolism inflammation

KW - Oncogene

KW - Proliferation

KW - Rho GTPases

KW - Senescence

KW - Survival

KW - Transformation

KW - Tumor progression

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Rho GTPases modulate malignant transformation of tumor cells

Abstract

Keywords

UN SDGs

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