Abstract
Rho GTPases are well known for their roles in regulating cell migration, and also contribute to a variety of other cellular responses. They are subdivided into 2 groups: typical and atypical. The typical Rho family members, including RhoA, Rac1 and Cdc42, cycle between an active GTP-bound and inactive GDP-bound conformation, and are regulated by GEFs, GAPs and GDIs, whereas atypical Rho family members have amino acid substitutions that alter their ability to interact with GTP/GDP and hence are regulated by different mechanisms. Both typical and atypical Rho GTPases contribute to cancer progression. In a few cancers, RhoA or Rac1 are mutated, but in most cancers expression levels and/or activity of Rho GTPases is altered. Rho GTPase signaling could therefore be therapeutically targeted in cancer treatment.
| Original language | English |
|---|---|
| Pages (from-to) | 207-221 |
| Number of pages | 15 |
| Journal | Small GTPases |
| Volume | 7 |
| Issue number | 4 |
| Early online date | 14 Sept 2016 |
| DOIs | |
| Publication status | Published - 1 Oct 2016 |
Keywords
- cancer progression
- cell migration
- Rho GTPases
- signal transduction
