Rho, ROCK and actomyosin contractility in metastasis as drug targets [version 1; referees: 2 approved]

Irene Rodriguez-Hernandez, Gaia Cantelli, Fanshawe Bruce, Victoria Sanz-Moreno*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

51 Citations (Scopus)
150 Downloads (Pure)

Abstract

Metastasis is the spread of cancer cells around the body and the cause of the majority of cancer deaths. Metastasis is a very complex process in which cancer cells need to dramatically modify their cytoskeleton and cope with different environments to successfully colonize a secondary organ. In this review, we discuss recent findings pointing at Rho-ROCK or actomyosin force (or both) as major drivers of many of the steps required for metastatic success. We propose that these are important drug targets that need to be considered in the clinic to palliate metastatic disease.

Original languageEnglish
Article number783
JournalF1000Research
Volume5
DOIs
Publication statusPublished - 29 Apr 2016

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