Rho, ROCK and actomyosin contractility in metastasis as drug targets [version 1; referees: 2 approved]

TY - JOUR

T1 - Rho, ROCK and actomyosin contractility in metastasis as drug targets [version 1; referees

T2 - 2 approved]

AU - Rodriguez-Hernandez, Irene

AU - Cantelli, Gaia

AU - Bruce, Fanshawe

AU - Sanz-Moreno, Victoria

PY - 2016/4/29

Y1 - 2016/4/29

N2 - Metastasis is the spread of cancer cells around the body and the cause of the majority of cancer deaths. Metastasis is a very complex process in which cancer cells need to dramatically modify their cytoskeleton and cope with different environments to successfully colonize a secondary organ. In this review, we discuss recent findings pointing at Rho-ROCK or actomyosin force (or both) as major drivers of many of the steps required for metastatic success. We propose that these are important drug targets that need to be considered in the clinic to palliate metastatic disease.

AB - Metastasis is the spread of cancer cells around the body and the cause of the majority of cancer deaths. Metastasis is a very complex process in which cancer cells need to dramatically modify their cytoskeleton and cope with different environments to successfully colonize a secondary organ. In this review, we discuss recent findings pointing at Rho-ROCK or actomyosin force (or both) as major drivers of many of the steps required for metastatic success. We propose that these are important drug targets that need to be considered in the clinic to palliate metastatic disease.

UR - http://www.scopus.com/inward/record.url?scp=85011003007&partnerID=8YFLogxK

U2 - 10.12688/F1000RESEARCH.7909.1

DO - 10.12688/F1000RESEARCH.7909.1

M3 - Article

AN - SCOPUS:85011003007

SN - 2046-1402

VL - 5

JO - F1000Research

JF - F1000Research

M1 - 783

ER -